{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:32:57Z","timestamp":1774870377350,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171105"],"award-info":[{"award-number":["82171105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271135"],"award-info":[{"award-number":["82271135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) is predominantly associated with type 2 inflammation (85.4%) and significant disease severity. This study aims to investigate the overall control status of CRSwNP patients one to seven years after endoscopic sinus surgery (ESS) and identify the real\u2010world factors influencing these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 427 adult patients diagnosed with primary diffuse CRSwNP who underwent bilateral ESS performed by a senior, well\u2010trained surgeon between 2017 and 2022. Among them, 315 patients completed follow\u2010ups in January 2024. Data collected included demographic information, comorbidities, symptom questionnaires (VAS, TNSS, SNOT\u201022), blood test results, nasal endoscopic scores, and Lund\u2010Mackay CT scores. The clinical control status was assessed postoperatively using EPOS 2020 criteria. Ordinal logistic regression was used to analyze the factors influencing postoperative control status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow\u2010up period was 34\u2009months. The most pronounced symptom is a decline in olfactory function (VAS 8, IQR: 4\u201310), followed by nasal obstruction (VAS 7, IQR: 5\u20139) before surgery. Generally, postoperative outcomes showed that 54.6% of patients achieved controlled status, 30.2% were partly controlled, and 15.2% remained uncontrolled. A high blood eosinophil ratio (&gt;\u20094.75%), worse smell VAS scores (&gt;\u20099.5), and higher Lund\u2010Mackay CT scores (&gt;\u200914.5) were associated with poorer control status, whereas medication adherence significantly improved postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Proper surgical techniques combined with good medication adherence play a crucial role in improving postoperative outcomes for CRSwNP patients, including those with type 2 inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32363","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T03:44:22Z","timestamp":1751082262000},"page":"4588-4599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Outcomes of Optimized Surgery and Medication in Chronic Rhinosinusitis With Nasal Polyps"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-3702","authenticated-orcid":false,"given":"Wendong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Otorhinolaryngology Institute Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Shenzhen People's Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Affiliated Hospital of Jinan University, The Second People's Hospital of Shunde  Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Guangdong Clifford Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xialin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Guangdong Clifford Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-3282","authenticated-orcid":false,"given":"Fenghong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Otorhinolaryngology Institute Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.10.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3142"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.04.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26391"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-019-0269-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S350609"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613211019716"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111540"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4231"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin17.240"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27267"},{"issue":"29","key":"e_1_2_8_13_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens W. J.","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.050"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22234"},{"issue":"4","key":"e_1_2_8_16_1","first-page":"261","article-title":"A Retrospective Study of Changes of Histopathology of Nasal Polyps in Adult Chinese in Central China","volume":"57","author":"Jiang W. X.","year":"2019","journal-title":"Rhinology"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00183169"},{"issue":"6","key":"e_1_2_8_18_1","first-page":"459","article-title":"Transnasal Endoscopic Frontal Sinus Surgery Using Expanded Agger Nasi Approach","volume":"46","author":"Shi J. B.","year":"2011","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"2","key":"e_1_2_8_19_1","first-page":"130","article-title":"Endotype\u2010Based Surgical Treatment of Chronic Rhinosinusitis","volume":"57","author":"Shi J. B.","year":"2022","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"10","key":"e_1_2_8_20_1","first-page":"990","article-title":"Position Paper on Diagnosis and Treatment of Type 2 Chronic Rhinosinusitis","volume":"59","author":"Shi J. B.","year":"2024","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420936196"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.32363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:06:58Z","timestamp":1765876018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.32363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/lary.32363"],"URL":"https:\/\/doi.org\/10.1002\/lary.32363","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"assertion":[{"value":"2025-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}