{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:39:37Z","timestamp":1792003177379,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study is to define the prognostic role of further stratification in oral tongue and floor squamous cell carcinoma (OTFSCC) with a pathological DOI &gt;\u200910\u2009mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter study was conducted on patients with a pDOI &gt;\u200910\u2009mm. Patients were stratified into three groups based on pDOI values: Group A (11\u201320\u2009mm), Group B (21\u201330\u2009mm) and group C (&gt;\u200930\u2009mm). The association between stratified pDOI and various histopathological features was investigated, along with disease\u2010free survival (DFS), disease\u2010specific survival (DSS), and overall survival (OS). Univariable and multivariable Cox regression analyses were applied to estimate the hazard ratio (HR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 108 patients were included. Seventy\u2010six patients (70.4%) were in Group A, 22 (20.4%) in Group B, and 10 (9.2%) in Group C. The association between the stratified pDOI and ENE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), lymph node burden (LNB) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and lymph node ratio (LNR) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) resulted statistically significant. Five\u2010year DSS resulted in 72.5% for Group A, 53.3% for Group B, and 25.9% for Group C. Univariable analysis showed that a pDOI &gt;\u200930\u2009mm was associated with a statistically significant increased risk of recurrence (HR\u2009=\u20098.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000) and mortality from disease (HR\u2009=\u20093.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The stratification of OTFSCCs with a pDOI &gt;\u200910\u2009mm was statistically significantly associated with ENE, LNB, and LNR. Pathological DOI &gt;\u200930\u2009mm emerged as a negative prognostic factor for DFS and DSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level 3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32384","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:13:12Z","timestamp":1752063192000},"page":"4724-4731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Role of Depth of Invasion Stratification Beyond the 10\u2009mm Threshold in Tongue Carcinoma"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6919-6928","authenticated-orcid":false,"given":"Maria","family":"Rosini","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Azienda Ospedaliero\u2010Universitaria Policlinico di Modena, University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-7249","authenticated-orcid":false,"given":"Costanza","family":"Galloni","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Azienda Ospedaliero\u2010Universitaria Policlinico di Modena, University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gazzini","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Provincial Hospital of Bolzano (SABES\u2010ASDAA)  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-1299","authenticated-orcid":false,"given":"Edorardo","family":"Serafini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna  Bologna Italy"},{"name":"Otolaryngology and Audiology Unit IRCCS Azienda Ospedaliero\u2010Universitaria of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Zanghi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Provincial Hospital of Bolzano (SABES\u2010ASDAA)  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-9277","authenticated-orcid":false,"given":"Bianca Maria","family":"Festa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Rozzano Italy"},{"name":"Otorhinolaryngology Unit IRCSS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Del Giovane","sequence":"additional","affiliation":[{"name":"Unit of Statistical and Methodological Support to Clinical Research University Hospital of Modena  Modena Italy"},{"name":"Institute of Primary Health Care (BIHAM), University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Lupi","sequence":"additional","affiliation":[{"name":"Department of Pathology Azienda Ospedaliero\u2010Universitaria Policlinico di Modena, University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Marchioni","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Azienda Ospedaliero\u2010Universitaria Policlinico di Modena, University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Provincial 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