{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:49:54Z","timestamp":1782791394403,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014882","name":"Department of Finance of Hebei","doi-asserted-by":"publisher","award":["ZF2025004"],"award-info":[{"award-number":["ZF2025004"]}],"id":[{"id":"10.13039\/501100014882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the role of fine needle aspiration thyroglobulin (FNA\u2010TG) and fine needle aspiration cytokeratin 19 fragment antigen 21\u20101 (FNA\u2010CYFRA 21\u20101) in the diagnosis of cervical lymph node metastasis of differentiated thyroid carcinoma (DTC), then analyze whether different neck lymph node compartmentalization affected the cut\u2010off values of FNA\u2010TG and FNA\u2010CYFRA 21\u20101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and sixteen lymph nodes with suspicious ultrasound signs between September 2023 and September 2024 were analyzed, and the lymph nodes were classified into central lymph nodes and lateral neck nodes, and all lymph nodes underwent fine needle aspiration cytology (FNAC), FNA\u2010TG, and FNA\u2010CYFRA 21\u20101 preoperatively. Differences in the levels of FNA\u2010TG and FNA\u2010CYFRA 21\u20101 in the lateral neck nodes and central lymph nodes were analyzed, and the optimal cut\u2010off values of the two were calculated to further analyze the value of FNAC, FNA\u2010TG, and FNA\u2010CYFRA 21\u20101 for diagnosis alone and in combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the non\u2010metastatic lymph node group, the difference in FNA\u2010TG levels between the lateral neck zone and the central zone was statistically significant. The levels of FNA\u2010CYFRA 21\u20101 were not affected by the zoning of the cervical lymph nodes. In the lateral neck region, the area under the diagnostic curve was highest for the combination of the three.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FNA\u2010CYFRA 21\u20101 is valuable in DTC cervical lymph node metastasis and can assist in the diagnosis of FNAC and FNA\u2010TG, especially in suspected centralized lymph nodes that are not diagnosed preoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32426","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:59:16Z","timestamp":1752911956000},"page":"4459-4466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of\n                    <scp>FNA<\/scp>\n                    \u2010\n                    <scp>CYFRA<\/scp>\n                    21\u20101 in Cervical Lymph Node Metastasis of Differentiated Thyroid Cancer"],"prefix":"10.1002","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8851-3802","authenticated-orcid":false,"given":"Xiuqiao","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Hebei General Hospital  Shijiazhuang China"},{"name":"School of Graduate Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Hebei General Hospital  Shijiazhuang 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