{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:47:19Z","timestamp":1787507239075,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009568","name":"Universidade Estadual Paulista","doi-asserted-by":"publisher","award":["1699\/2023"],"award-info":[{"award-number":["1699\/2023"]}],"id":[{"id":"10.13039\/501100009568","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Multiple myeloma is a malignancy characterized by clonal proliferation of plasma cells in the bone marrow. The treatment of patients with relapsed or refractory multiple myeloma remains a challenge. Talquetamab is a recently approved drug, a first\u2010in\u2010class GPRC5D\u2010targeting T\u2010cell redirecting bispecific antibody, for treatment of patients with triple\u2010class exposed relapsed\/refractory multiple myeloma. Patients who underwent drug therapy have experienced oral side effects such as xerostomia and dysgeusia. This report describes the case of a 61\u2010year old man with triple\u2010class exposed refractory multiple myeloma who developed talquetamab\u2010related dysgeusia that was successfully treated with photobiomodulation (PBM). The patient began to complain of loss of taste three days after the administration of talquetamab. PBM was performed every 48\u2009h with 25 J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    per treatment field using the Therapy EC device (DMC; model number: #75153; red: 660 nm \u00b110 nm; infrared: 808 nm \u00b110 nm; fixed power of 100 mW \u00b120%; beam area of 0.04 cm\n                    <jats:sup>2<\/jats:sup>\n                    , and irradiance of 2.5 W\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) during the talquetamab escalation phase. The application of laser was performed in 78 points distributed throughout the oral cavity. After 7\u2009days\/third session of PBM, the patient displayed a significant improvement in sensitivity to tastes, mainly salty and bitter. After 7\u2009weeks of follow\u2010up, there was a slight reduction in sensibility to salty and no change in other tastes. The current clinical report demonstrated the potential effectiveness of a PBM protocol developed for the treatment of talquetamab\u2010related dysgeusia. The management of this oral side effect using PBM could prevent treatment interruption and improve the patients' quality of life.\n                  <\/jats:p>","DOI":"10.1002\/lary.32445","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:29:03Z","timestamp":1752755343000},"page":"236-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Talquetamab\u2010Induced Dysgeusia Successfully Treated With Photobiomodulation Therapy"],"prefix":"10.1002","volume":"136","author":[{"given":"Giseli Mitsuy","family":"Kayahara","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry, S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raissa Baisso","family":"Espinhosa","sequence":"additional","affiliation":[{"name":"Oral Oncology Center S\u00e3o Paulo State University (Unesp), School of Dentistry  Ara\u00e7atuba, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffani Nascimento","family":"da Silva","sequence":"additional","affiliation":[{"name":"Oral Oncology Center S\u00e3o Paulo State University (Unesp), School of Dentistry  Ara\u00e7atuba, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Aparecida Sanches","family":"Pereira","sequence":"additional","affiliation":[{"name":"Oral Oncology Center S\u00e3o Paulo State University (Unesp), School of Dentistry  Ara\u00e7atuba, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Galera","family":"Bernab\u00e9","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry, S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba, S\u00e3o Paulo Brazil"},{"name":"Oral Oncology Center S\u00e3o Paulo State University (Unesp), School of Dentistry  Ara\u00e7atuba, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauco Issamu","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry, S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba, S\u00e3o Paulo Brazil"},{"name":"Oral Oncology Center S\u00e3o Paulo State University (Unesp), School of Dentistry  Ara\u00e7atuba, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Stuchi","family":"Urazaki","sequence":"additional","affiliation":[{"name":"Cancer Center Treatment Santa Casa de Misericordia Hospital  Ara\u00e7atuba, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Macedo","family":"Cortopassi","sequence":"additional","affiliation":[{"name":"Cancer Center Treatment Santa Casa de Misericordia Hospital  Ara\u00e7atuba, S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4434-6057","authenticated-orcid":false,"given":"Vitor Bonetti","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry, S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba, S\u00e3o Paulo Brazil"},{"name":"Oral Oncology Center S\u00e3o Paulo State University (Unesp), School of Dentistry  Ara\u00e7atuba, S\u00e3o Paulo 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