{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:17:50Z","timestamp":1791253070896,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","award":["Young Investigator Award"],"award-info":[{"award-number":["Young Investigator Award"]}],"id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R38HL167238\u201001"],"award-info":[{"award-number":["1R38HL167238\u201001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P500PM_203194"],"award-info":[{"award-number":["P500PM_203194"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize the incidence, mortality, and disparities in head and neck cancer (HNC) across Southeast Asia (SEA) in 2022 and project trends to 2050 to inform cancer planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a population\u2010based analysis using 2022 Global Cancer Observatory data from 11 SEA countries. We analyzed cancers of the lip and oral cavity, salivary glands, oropharynx, nasopharynx, hypopharynx, larynx, and thyroid. Age\u2010standardized incidence and mortality rates (ASIR and ASMR) were calculated using the Segi\u2010Doll world standard. Projections to 2050 were based on demographic changes using UN World Population Prospects data, assuming stable incidence and mortality rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Myanmar had the highest oral cancer rates (ASIR: 6.6 males, 2.6 females; ASMR: 3.9 males, 1.6 females). Elevated salivary gland cancer incidence was observed in Indonesia, the Philippines, and Singapore. Oropharyngeal cancers showed strong male predominance in Myanmar (ASIR ratio: 10:1). Nasopharyngeal cancer incidence in Brunei and Indonesia exceeded global averages (ASIR: 9.8 and 9.6 males). Projections to 2050 estimate 47,000 new male cases and 28,200 new female cases in Indonesia, with 30,600 male deaths and 12,200 female deaths. While SEA's overall ASIR for HNC (18.0) was comparable to the global average (18.9), the ASMR was significantly higher (9.5 vs. 5.3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The rising burden of HNC in SEA highlights urgent disparities in incidence and mortality. Targeted prevention, early detection, and investment in cancer care systems are essential to mitigate future disease burden and improve outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III\u2014Epidemiologic study using population\u2010based registry data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.32450","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T13:29:43Z","timestamp":1753277383000},"page":"4742-4753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Head and Neck Cancer in Southeast Asia: 2022 Incidence, Mortality, and Projections to 2050"],"prefix":"10.1002","volume":"135","author":[{"given":"Jenny","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryan","family":"Selokar","sequence":"additional","affiliation":[{"name":"University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances Dominique V.","family":"Ho","sequence":"additional","affiliation":[{"name":"College of Medicine, University of the Philippines  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa E.","family":"Jacomina","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Benavides Cancer Institute, University of Santo Tomas Hospital  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin Jay G.","family":"Feliciano","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health, Ateneo de Manila University  Pasig 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Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhav","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Health Policy Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod Carlo","family":"Columbres","sequence":"additional","affiliation":[{"name":"Center for Cancer Research National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"},{"name":"College of Osteopathic Medicine William Carey University  Hattiesburg Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teeradon","family":"Treechairusame","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"},{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York New York 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