{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:24:14Z","timestamp":1790162654848,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010001857"],"award-info":[{"award-number":["UL1\u2010TR\u2010001857"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To determine the efficacy of acid suppression therapy (AST) for the treatment of gastroesophageal reflux (GER) and airway symptoms in infants with mild to moderate laryngomalacia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n From 2020 to 2023, infants \u2264\u20096\u2009months old with laryngomalacia at a tertiary children's hospital were randomized to famotidine and feeding modifications (AST) or feeding modifications alone (no\u2010AST). Laryngomalacia Airway Symptom Score (LASS) and Infant Gastroesophageal Reflux Questionnaire (I\u2010GERQ\u2010R) were completed by guardians. Of 343 patients approached, 257 were excluded due to severe laryngomalacia on LASS, severe GER (I\u2010GERQ\u2010\n R<\/jats:italic>\n \u2009\u2265\u200916), prior AST, no laryngomalacia on laryngoscopy, recommendation for supraglottoplasty, and\/or other airway anomalies. Twenty\u2010one declined participation. LASS and I\u2010GERQ\u2010R were again completed 1\u20136\u2009months following enrollment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty\u2010five patients enrolled; 40\/65 (62%) followed up at a mean of 3.1\u2009months (SD 1.4\u2009months). Of these 40, 10 (25%) had mild and 30 (75%) had moderate laryngomalacia. Median I\u2010GERQ\u2010R was 11 (range 5\u201315) at the initial appointment and 7.5 (range 0\u201326) at follow\u2010up (\n p<\/jats:italic>\n \u2009=\u20090.002). Laryngomalacia resolved in 13\/40 (33%) at follow\u2010up based on LASS (\n p<\/jats:italic>\n \u2009<\u20090.001). Patients randomized to AST (\n n<\/jats:italic>\n \u2009=\u200920) and no\u2010AST (\n n<\/jats:italic>\n \u2009=\u200920) had comparable improvement on LASS (\n p<\/jats:italic>\n \u2009=\u20090.3) and I\u2010GERQ\u2010R (\n p<\/jats:italic>\n \u2009=\u20090.8). Additionally, the severity of laryngomalacia at initial consult did not have a significant impact on LASS (\n p<\/jats:italic>\n \u2009=\u20090.3) or I\u2010GERQ\u2010R (\n p<\/jats:italic>\n \u2009=\u20090.8) improvement. LASS (\n \u03c1<\/jats:italic>\n \u2009=\u20090.423,\n p<\/jats:italic>\n \u2009=\u20090.007) but not I\u2010GERQ\u2010R (\n \u03c1<\/jats:italic>\n \u2009=\u20090.122,\n p<\/jats:italic>\n \u2009=\u20090.5) improved more with longer time from consult to follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This small randomized controlled trial was unable to demonstrate additional benefit from AST compared to feeding modifications alone based on airway and reflux symptoms.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n https:\/\/clinicaltrials.gov\/study\/NCT04614974<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.32471","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T11:18:52Z","timestamp":1754392732000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acid Suppression in Mild\u2010Moderate Laryngomalacia Without\n GERD<\/scp>\n : A Randomized Controlled Trial"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5783-9198","authenticated-orcid":false,"given":"Amber D.","family":"Shaffer","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Balogun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison B. J.","family":"Tobey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Maguire","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-0281","authenticated-orcid":false,"given":"Jeffrey P.","family":"Simons","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Dohar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-4493","authenticated-orcid":false,"given":"Jennifer L.","family":"Mccoy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Rushchak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-7816","authenticated-orcid":false,"given":"Reema","family":"Padia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.31729\/jnma.5244"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.04.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/753526"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25440"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283405e48"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.04.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103434"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9128"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.02.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537\u2010199911000\u201000009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.06.051"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3758\/bf03193146"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.06.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.722"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010020\u20100932\u20104"}],"container-title":["The 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