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Ouabain produced a pronounced interference with energy utilization of the stria vascularis. The \u201cloop\u201d diuretics ethacrynic acid and furosemide produced a reduction of energy utilization of a lesser degree than did ouabain. The \u201cloop\u201d diuretics do not seem to exert their toxic action upon strial Na+K+\u2010ATPase, but may act by interfering with strial adenylate cyclase. Aminoglycoside antibiotics and diuretic and nondiuretic mercurials seem to exert their primary noxious action upon cochlear function by interfering with membrane processes of the structures bounding the cochlear duct.<\/jats:p>","DOI":"10.1002\/lary.5540870506","type":"journal-article","created":{"date-parts":[[2009,10,20]],"date-time":"2009-10-20T13:49:14Z","timestamp":1256046554000},"page":"699-721","source":"Crossref","is-referenced-by-count":18,"title":["Noxious effects upon cochlear metabolism"],"prefix":"10.1002","volume":"87","author":[{"given":"R.","family":"Thalmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Thalmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Ise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Paloheimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,20]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Experiments in Hearing","author":"Von B\u00e9k\u00e9sy G.","year":"1960"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1965.030.01.020"},{"key":"e_1_2_1_4_2","unstructured":"HonrubiaV. 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