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Histopathology of temporal bones from children who die with cytomegalic inclusion disease shows viral infected cells in non\u2010sensory endolabyrinthine epithelium. Experimental mouse cytomegalovirus causes an age related cranial neuronitis and perilabyrinthitis. Immunopathologic localization of different viral antigens in experimental inner ear infections shows differential vulnerability of labyrinthine structures to infections. Adaptation of such techniques to human temporal bone, pathology could yield information regarding pathogenesis of viral labyrinthitis. The development of a human cytomegalovirus vaccine may eliminate the risks of this congenital infection.<\/jats:p>","DOI":"10.1002\/lary.5540891017","type":"journal-article","created":{"date-parts":[[2009,10,20]],"date-time":"2009-10-20T13:58:29Z","timestamp":1256047109000},"page":"1681-1688","source":"Crossref","is-referenced-by-count":8,"title":["Congenital cytomegalovirus and hearing loss: Clinical and experimental observations"],"prefix":"10.1002","volume":"89","author":[{"given":"Gustave L.","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,20]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"The Herpesviruses","author":"Kaplan A. 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