{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:03:47Z","timestamp":1784365427289,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC012545"],"award-info":[{"award-number":["R01DC012545"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Laryngeal dystonia (LD) is a task\u2010specific focal dystonia marked by involuntary spasms in the laryngeal muscles during speech production. Sodium oxybate has recently been demonstrated as a new treatment option for alcohol\u2010responsive (EtOH+) LD patients.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The objective of this study is to evaluate the long\u2010term use of sodium oxybate for the treatment of LD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 149 LD patients were invited to complete the online survey study. Seventy\u2010seven patients (mean age 65.2\u2009\u00b1\u200911.5\u2009years, 54 females\/23 males) completed 21 questions related to their disorder and the use of sodium oxybate.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Six patients (7.8%) reported receiving a prescription of sodium oxybate for the treatment of their voice symptoms. Of these, three EtOH+ patients (50%) reported receiving 1\u20131.25\u2009g of sodium oxybate on an as\u2010needed basis, with an average of 79.3%\u2009\u00b1\u200920.0% reduction in self\u2010perceived voice symptoms following drug intake. Drug usage ranged from three times per day 5\u2009days per week to three times per month over the span of 6 months\u201312\u2009years. Patients reported experiencing mild side effects that lasted 1\u20132\u2009h, including drowsiness, dizziness, or nausea. The remaining three patients reported not being able to fill their prescriptions due to medical insurance reimbursements.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Despite the limited sample size, this study demonstrates that the long\u2010term daytime use of sodium oxybate for the treatment of voice symptoms is safe and effective for EtOH+ isolated focal LD patients. The study highlights medical insurance coverage as one of the limiting factors hindering LD patients from accessing this medication.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n Level 4.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.70054","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T15:44:54Z","timestamp":1755272694000},"page":"319-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Daytime Use of Sodium Oxybate in Laryngeal Dystonia: A Follow\u2010Up Online Survey Study"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6368-0793","authenticated-orcid":false,"given":"Lena C.","family":"O'Flynn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear and Harvard Medical School Boston Massachusetts USA"},{"name":"Program in Speech Hearing Bioscience and Technology Harvard University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-0437","authenticated-orcid":false,"given":"Kristina","family":"Simonyan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear and Harvard Medical School Boston Massachusetts USA"},{"name":"Program in Speech Hearing Bioscience and Technology Harvard University Boston Massachusetts USA"},{"name":"Department of Neurology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26381"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27121"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra044047"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-013-0158-x"},{"key":"e_1_2_8_6_1","volume-title":"Sodium Oxybate","author":"Dominguez A.","year":"2025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2016-0007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2024.07.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00892"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy128"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.03.028"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10090"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4375"},{"key":"e_1_2_8_14_1","article-title":"Long\u2010Term Effect of Sodium Oxybate (Xyrem\u00ae) in Spasmodic Dysphonia With Vocal Tremor","volume":"3","author":"Simonyan K.","year":"2013","journal-title":"Tremor and Other Hyperkinetic Movements (New York, N.Y.)"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-023-00351-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27549"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7751-2"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:20:27Z","timestamp":1771428027000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/lary.70054"],"URL":"https:\/\/doi.org\/10.1002\/lary.70054","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"assertion":[{"value":"2025-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}