{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:38:47Z","timestamp":1791232727052,"version":"4.1.0"},"reference-count":112,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To derive precise estimates of anxiety and depressive disorder prevalence in patients with common vestibular disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>CINAHL, Cochrane Library, PubMed, PsycINFO, and SCOPUS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis was reported per PRISMA guidelines. Outcomes included continuous measures (mean), proportions (%), and relative risks (RR) with 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010five studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009764,403) examining anxiety, depression, and vestibular disorders in adults were included. Mean ages were 50.3 (vestibular) and 46.7 (control); females comprised 63.8% and 64.3%, respectively.\n                    <\/jats:p>\n                    <jats:p>\n                      Patients with vestibular disorders had significantly higher rates and risks of anxiety (31.4% vs. 8.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001; RR\u2009=\u20091.50, 95% CI: 1.1\u20132.0) and depression (28.3% vs. 4.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001; RR\u2009=\u20092.9, 95% CI: 1.8\u20134.4) than controls. Elevated rates were observed in benign paroxysmal positional vertigo (30.6%, 23.6%), Meniere's disease (47.0%, 43.1%), vestibular migraine (46.5%, 35.7%), and vestibular neuritis (19.4%, 20.7%) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Episodic disorders showed higher prevalence than vestibular neuritis. Patients with unspecified peripheral vestibular disorders also had significantly higher anxiety (12.1%) and depression (13.2%) rates than controls.\n                    <\/jats:p>\n                    <jats:p>Meta\u2010regression revealed significant associations between Dizziness Handicap Inventory (DHI) scores and Hospital Anxiety and Depression Scale (HADS) anxiety and depression subscales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis offers the most precise prevalence and relative risk estimates of anxiety and depressive disorders in vestibular illness. The greater risk in episodic versus single\u2010event vestibular disorders may inform the understanding of vestibular\u2013psychiatric comorbidity mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70055","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T15:46:17Z","timestamp":1755272777000},"page":"535-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anxiety and Depression in Adults With Vestibular Disorders: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-4975","authenticated-orcid":false,"given":"Cory Hyun\u2010su","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Nova Southeastern University\u2014College of Osteopathic 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