{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T11:51:36Z","timestamp":1768218696627,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002014"],"award-info":[{"award-number":["UL1 TR002014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Branchial cleft cyst carcinomas (BCCC) are rare lateral neck malignancies thought to originate from branchial cleft remnants. Diagnosing primary BCCC should be approached with skepticism; cystic nodal metastasis must be excluded. Due to its rarity, we performed a comprehensive database study to better characterize the ongoing diagnosis of BCCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010arm retrospective cohort study using the TriNetX Research database. Patients \u2265\u200918\u2009years of age with a diagnosis of BCCC identified by ICD\u201010 C10.4 between 2008 and 2018 were included, allowing for up to 5\u2009years of follow\u2010up. Demographics, past medical history, oncologic history, diagnostic rate, treatment pathways, and 5\u2010year outcomes including diagnosis with primary HNC and Kaplan\u2013Meier survival curves were analyzed within TriNetX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 10\u2009years, 1070 patients diagnosed with BCCC were included. The mean age was 59.6\u2009\u00b1\u20099.7; the majority were male (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009810, 75.6%) and white (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009765, 71.4%). Incidence of BCCC increased from 2008 to 2015 and subsequently dropped precipitously. Almost all patients, 94.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091011), had prior or subsequent diagnosis of another HNC within 5\u2009years. Five\u2010year survival probability for BCCC was 56.0%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We describe the largest cohort of BCCC patients to date. Most patients were diagnosed with another HNC within 5\u2009years, suggesting a likely misdiagnosis of BCCC. A poor 5\u2010year survival rate may be secondary to a delay in appropriate treatment following an erroneous diagnosis, underscoring the need to approach a diagnosis of BCCC with caution. We consider the use of the BCCC code to be detrimental and recommend its discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70060","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:43:32Z","timestamp":1755859412000},"page":"766-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Branchial Cleft Cyst Carcinoma Remains Grossly Over Diagnosed: A Large Database Analysis"],"prefix":"10.1002","volume":"136","author":[{"given":"Andrew","family":"Meci","sequence":"first","affiliation":[{"name":"The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-1097","authenticated-orcid":false,"given":"Neerav","family":"Goyal","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Otolaryngology Penn State Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-4116","authenticated-orcid":false,"given":"David","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Otolaryngology Penn State Milton S. 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