{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:38:09Z","timestamp":1771511889068,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effect of topical dexamethasone on improving hearing outcomes and alleviating postoperative symptoms in patients diagnosed with otosclerosis who have undergone stapedotomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Randomized, single\u2010blinded clinical trial<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy patients diagnosed with otosclerosis were randomly divided into intervention and control groups and underwent stapedotomy with or without topical dexamethasone, respectively. Hearing outcomes and postoperative pain, vertigo, and tinnitus were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean improvement in the air\u2010bone gap (ABG) was 23.53\u2009\u00b1\u20098.70\u2009dB in the intervention group and 18.95\u2009\u00b1\u200911.66\u2009dB in the control group, with no statistically significant difference between the two groups (0.087). Speech Reception Threshold (SRT) and Word Recognition Score (WRS) improved more significantly in the dexamethasone group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004, respectively). Postoperative tinnitus and vertigo were significantly lower in the dexamethasone group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Applying dexamethasone during stapedotomy can reduce post\u2010operative vertigo and tinnitus. Although hearing outcomes were better in the intervention group, there was no statistically significant difference in ABG improvement between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70076","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:43:44Z","timestamp":1758627824000},"page":"948-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Topical Dexamethasone During Stapedotomy in Patients With Otosclerosis: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-241X","authenticated-orcid":false,"given":"Behrooz","family":"Amirzargar","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Research Center, Department of Otolaryngology\u2014Head and Neck Surgery, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6835-111X","authenticated-orcid":false,"given":"Sepideh","family":"Zoafa","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, Department of Otolaryngology\u2014Head and Neck Surgery, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-0007","authenticated-orcid":false,"given":"Melika","family":"Karimi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, Department of Otolaryngology\u2014Head and Neck Surgery, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Emami","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, Department of Otolaryngology\u2014Head and Neck Surgery, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Kouhi","sequence":"additional","affiliation":[{"name":"Otolaryngology Research Center, Department of Otolaryngology\u2014Head and Neck Surgery, Amir Alam Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Golparvaran","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center, Department of Otolaryngology\u2014Head and Neck Surgery, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.11.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-07880-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.11.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.3221"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1257"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0918-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1258732"},{"issue":"2","key":"e_1_2_7_9_1","first-page":"17","article-title":"Otosclerosis: An Update on Diagnosis and Treatment","volume":"30","author":"Batson L.","year":"2017","journal-title":"Journal of the American Academy of Physician 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