{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:04:58Z","timestamp":1788303898310,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Respiratory epithelial adenomatoid hamartoma (REAH) is an under\u2010recognized, nonneoplastic entity of uncertain etiology that occurs in isolation or in chronic rhinosinusitis (CRS). Our goal is to evaluate a single institutional experience with REAH over 15\u2009years and characterize and compare olfactory cleft (OC) REAH and extra\u2010OC REAH.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Retrospective review of pathology\u2010confirmed REAH at a single institution from2009 to 2024. Charts and imaging were reviewed to characterize presentation and outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n REAH was present in 88 patients who were 58.6\u2009\u00b1\u200915.6\u2009years of age, 58% (\n n<\/jats:italic>\n \u2009=\u200951) male, and 75% (\n n<\/jats:italic>\n \u2009=\u200966) white. OC\u2010REAH was diagnosed in 49 (55.7%) patients, and extra\u2010OC REAH in 39 (44.3%) patients. Patients with OC\u2010REAH were older (63.2\u2009\u00b1\u200912.4\u2009years vs. 52.8\u2009\u00b1\u200917.4\u2009years,\n p<\/jats:italic>\n \u2009=\u20090.002) and had higher rates of comorbid allergic rhinitis (67.3% vs. 33.3%,\n p<\/jats:italic>\n \u2009=\u20090.002), asthma (55.1% vs. 25.6%,\n p<\/jats:italic>\n \u2009=\u20090.005), and prior endoscopic sinus surgery (65.3% vs. 43.6%,\n p<\/jats:italic>\n \u2009=\u20090.04) when compared to extra\u2010OC REAH. Fourteen patients with extra\u2010OC REAH presented as a sinonasal mass that was located within the nasal cavity (\n n<\/jats:italic>\n \u2009=\u20097, 50%), the maxillary sinus (\n n<\/jats:italic>\n \u2009=\u20093, 21.4%), the middle meatus\/ethmoid sinus (\n n<\/jats:italic>\n \u2009=\u20093, 21.4%), and the sphenoid sinus (\n n<\/jats:italic>\n \u2009=\u20091, 7.1%). Three patients with extra\u2010OC REAH had REAH diagnosed in the setting of inverted papilloma. No patients had recurrence on surveillance endoscopy or imaging.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n REAH is a benign, incompletely understood entity with variable presentation. Patients with OC involvement are older, with higher rates of allergic rhinitis and asthma compared to those with no OC involvement. REAH can rarely present as a discrete mass sparing the OC, mimicking other sinonasal pathology.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 4.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.70079","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T07:25:48Z","timestamp":1756193148000},"page":"658-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Respiratory Epithelial Adenomatoid Hamartoma Characteristics of Extra\u2010Olfactory Cleft Disease"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-671X","authenticated-orcid":false,"given":"Jakob L.","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-1422","authenticated-orcid":false,"given":"Eugene","family":"Oh","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti P.","family":"Sajed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1898-0417","authenticated-orcid":false,"given":"Daniel M.","family":"Beswick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-855X","authenticated-orcid":false,"given":"Jivianne T.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilene B.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400809"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3905"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21083"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24778"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22399"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3345"},{"key":"e_1_2_9_8_1","first-page":"264","article-title":"Respiratory Adenomatoid Hamartoma Must be Suspected on CT Scan Enlargement of the Olfactory Clefts","volume":"44","author":"Lima N. 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