{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:17:40Z","timestamp":1774423060901,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Local effects of pituitary hormones in the sinonasal region are not well characterized. We sought to examine sinonasal quality of life outcomes in functional and non\u2010functional pituitary tumors after endoscopic skull base surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective Medical Record Review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three hundred four patients who received endoscopic resection of a pituitary tumor at a tertiary skull base center reviewed. This population was divided into non\u2010functional and functional groups. Surgical outcomes and pre and postoperative quality of life scores were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Preoperative total SNOT 22 scores were not different overall between the two groups, but the rhinologic and extra\u2010nasal rhinologic subdomain scores in the functional group were higher than in the non\u2010functional group (3.57\u2009\u00b1\u20093.95 vs. 2.58\u2009\u00b1\u20093.64, and 1.48\u2009\u00b1\u20092.2 vs. 0.92\u2009\u00b1\u20091.75 respectively) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04 and 0.02). Change from baseline in overall postoperative SNOT 22 score was significantly greater in the functional group at 6\u2009weeks post\u2010operation (6.75\u2009\u00b1\u200917.51 vs. 1.4\u2009\u00b1\u200916.83 respectively) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Time to normalization on nasal endoscopy was longer in the functional group compared to the non\u2010functional group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Corticotrophic and somatotrophic tumors affect quality of life both pre\u2010 and post\u2010operation. Patients with functional tumors took longer to reach full healing and normalization of the sinus cavity. These findings can be used to counsel patients about different expectations during the immediate postoperative healing period, but also to reassure them that regardless of tumor functionality, they will be able to reach a good quality of life after endoscopic skull base surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70116","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:28:53Z","timestamp":1758108533000},"page":"631-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functionality of Pituitary Tumors Impacts Sinonasal Quality of Life Before and After Endoscopic Surgery"],"prefix":"10.1002","volume":"136","author":[{"given":"Yossawee","family":"Wongworawut","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Thammasat University  Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-4675","authenticated-orcid":false,"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-0861","authenticated-orcid":false,"given":"Jayakar V.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Dodd","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Stanford University School of Medicine  Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Fernandez\u2010Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Stanford University School of Medicine  Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2072-982X","authenticated-orcid":false,"given":"Zara M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine  Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.10.JNS141624"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-012-1473-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.11.212"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22398"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz559"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2014.12.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.170"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700730R"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094288"},{"issue":"5","key":"e_1_2_8_11_1","first-page":"455","article-title":"Pituitary Disease","volume":"28","author":"Pullan P.","year":"1999","journal-title":"Australian Family Physician"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"6","article-title":"Pituitary Hyperfunction Syndromes","volume":"1","author":"Silvestrini G. 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