{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:30:59Z","timestamp":1788827459295,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["ZEMKE19A0"],"award-info":[{"award-number":["ZEMKE19A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n People with Cystic Fibrosis (\n CF<\/jats:styled-content>\n ) experience significant sinonasal airway opacification, leading to chronic airway\u2010related conditions. The triple combination therapy Elexacaftor\/Tezacaftor\/Ivacaftor (\n ETI<\/jats:styled-content>\n ) has emerged as a therapeutic option for\n CF<\/jats:styled-content>\n . This study uses volumetric quantification technique to evaluate changes in\n CF<\/jats:styled-content>\n sinonasal airway patency pre\u2010\n ETI<\/jats:styled-content>\n and post\u2010\n ETI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Anatomically accurate person\u2010specific three\u2010dimensional sinonasal airspaces were reconstructed from radiographical images of 19 people (12 male, 7 female) with\n CF<\/jats:styled-content>\n , pre\u2010\n ETI<\/jats:styled-content>\n and post\u2010\n ETI<\/jats:styled-content>\n . Sinonasal airspace surface area, volume, and surface\u2010area\u2010to\u2010volume ratio were calculated pre\u2010\n ETI<\/jats:styled-content>\n and post\u2010\n ETI<\/jats:styled-content>\n . Pre\u2010\n ETI<\/jats:styled-content>\n and post\u2010\n ETI<\/jats:styled-content>\n sinonasal airspace changes in these computed parameters were corrected with changes in both Lund\u2010Mackay and\n SNOT<\/jats:styled-content>\n \u201022 scores.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Median (\n IQR<\/jats:styled-content>\n ) surface area and volume increased significantly from pre\u2010\n ETI<\/jats:styled-content>\n (Surface Area: 251.97\u2009cm\n 2<\/jats:sup>\n (43.71); Volume: 44.86\u2009cm\n 3<\/jats:sup>\n (20.72)) to post\u2010\n ETI<\/jats:styled-content>\n (Surface Area: 295.77\u2009cm\n 2<\/jats:sup>\n (31.34); Volume: 61.03\u2009cm\n 3<\/jats:sup>\n (14.21)), with respective\n p<\/jats:italic>\n \u2009<\u20090.01 per computed parameter. Furthermore, median surface\u2010area\u2010to\u2010volume ratio (\n IQR<\/jats:styled-content>\n ) was significantly different; pre\u2010\n ETI<\/jats:styled-content>\n : 0.053\u2009cm\n \u22121<\/jats:sup>\n (0.007); post\u2010\n ETI<\/jats:styled-content>\n : 0.052\u2009cm\n \u22121<\/jats:sup>\n (0.013);\n p<\/jats:italic>\n \u2009=\u20090.04. Pre\u2010\n ETI<\/jats:styled-content>\n to post\u2010\n ETI<\/jats:styled-content>\n improvement changes in surface area and volume significantly correlated with corresponding changes in Lund\u2010Mackay scores (Surface Area:\n R<\/jats:italic>\n \u2009=\u2009\u22120.78,\n p<\/jats:italic>\n \u2009<\u20090.01; Volume:\n R<\/jats:italic>\n \u2009=\u2009\u22120.68,\n p<\/jats:italic>\n \u2009<\u20090.01), but correlated weakly with corresponding changes in patient\u2010reported\n SNOT<\/jats:styled-content>\n \u201022 scores (Surface Area:\n R<\/jats:italic>\n \u2009=\u2009\u22120.13,\n p<\/jats:italic>\n \u2009=\u20090.62; Volume:\n R<\/jats:italic>\n \u2009=\u2009\u22120.06,\n p<\/jats:italic>\n \u2009=\u20090.82).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n People with\n CF<\/jats:styled-content>\n treated with\n ETI<\/jats:styled-content>\n exhibited a significant increase in sinonasal airway patency, as evidenced by volumetric quantification analysis of surface area and volume differences. These increases in both parameters showed strong significant correlations with Lund\u2010Mackay scores; however, no such correlations were observed with\n SNOT<\/jats:styled-content>\n \u201022 scores.\n <\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 4.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.70156","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:22:06Z","timestamp":1758799326000},"page":"622-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Elexacaftor\/Tezacaftor\/Ivacaftor on the Sinonasal Airspace in Cystic Fibrosis"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0096-8276","authenticated-orcid":false,"given":"Michelle H.","family":"Kim","sequence":"first","affiliation":[{"name":"School of Medicine Duke University Durham North Carolina USA"},{"name":"Department of Head and Neck Surgery & Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Luzum","sequence":"additional","affiliation":[{"name":"School of Medicine Duke University Durham North Carolina USA"},{"name":"Department of Head and Neck Surgery & Communication Sciences Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Kimple","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head & Neck Surgery University of North Carolina School of Medicine Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C.","family":"Zemke","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care and Sleep Medicine University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-8355","authenticated-orcid":false,"given":"Dennis","family":"Frank\u2010Ito","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery & Communication Sciences Duke University Durham North Carolina USA"},{"name":"Computational Biology & Bioinformatics PhD Program Duke University Durham North Carolina USA"},{"name":"Department of Mechanical Engineering and Materials Science Duke University Durham North Carolina 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