{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:15:10Z","timestamp":1772990110796,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective (s)<\/jats:title>\n                    <jats:p>Idiopathic and granulomatosis with polyangiitis (GPA)\u2010related subglottic stenosis (SGS) are considered distinct immune\u2010mediated inflammatory disorders. Limited data exist on serum inflammatory markers, specifically C\u2010Reactive Protein (CRP), for SGS diagnosis, differentiation, and prognostication. The study objective was the characterization of CRP levels in idiopathic (iSGS) and GPA\u2010SGS to assess CRP's ability to distinguish SGS subtypes and predict SGS progression and recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of patients with idiopathic or GPA\u2010SGS from 2007 to 2024 at a single institution. Surgery\u2010free interval (SFI) was calculated as the time between surgical interventions. Statistical analysis included independent t\u2010tests, chi\u2010squared, and univariate linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      59 iSGS and 47 GPA\u2010SGS patients were included. CRP was elevated in 36% of iSGS and 49% of GPA\u2010SGS patients (0.0.6\u2009mg\/dL). Mean maximum CRP was 2.7\u2009mg\/dL lower in iSGS compared to anti\u2010neutrophil cytoplasmic antibody (ANCA)\u2010positive GPA\u2010SGS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). The maximum CRP in iSGS was 3.6\u2009mg\/dL, while 10 (21%) GPA patients had CRPs greater than 3.6\u2009mg\/dL (max\u2009=\u200931\u2009mg\/dL). ANCA\u2010negative GPA\u2010SGS mean CRP was not significantly different than iSGS or ANCA\u2010positive GPA\u2010SGS. CRP and SFI did not correlate on univariate linear analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mild elevation of CRP is common in SGS patients. High CRP levels are more frequent in GPA\u2010SGS, potentially aiding clinical differentiation of etiologies. However, CRP at presentation does not appear to correlate with disease recurrence in iSGS or GPA\u2010related SGS, limiting its value as a biomarker and prognostic tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70167","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T11:56:06Z","timestamp":1758714966000},"page":"1320-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["C\u2010Reactive Protein Serum Values in Idiopathic and Autoimmune Subglottic Stenosis"],"prefix":"10.1002","volume":"136","author":[{"given":"Andrew J.","family":"Neevel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Michigan  Ann Arbor USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Ramazani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Michigan  Ann Arbor USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology University of Michigan  Ann Arbor USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ora","family":"Gewurz\u2010Singer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology University of Michigan  Ann Arbor USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1783-4338","authenticated-orcid":false,"given":"Norman D.","family":"Hogikyan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Michigan  Ann Arbor USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-8542","authenticated-orcid":false,"given":"Robert J.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Michigan  Ann Arbor USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robbi A.","family":"Kupfer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Michigan  Ann Arbor USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13665\u2010022\u201000286\u20106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26098"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28712"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818803584"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415610588"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31934"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez217"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.1135"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.11.43"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.07.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.05.006"},{"key":"e_1_2_9_13_1","unstructured":"S. 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