{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:30:51Z","timestamp":1778527851239,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222196"],"award-info":[{"award-number":["7222196"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate hypoalbuminemia's role in Reinke's edema (RE) development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was conducted at a single tertiary medical center between 2021 and 2024, which compared 41 hypoalbuminemia patients (total protein [TP]\u2009&lt;\u200960\u2009g\/L, albumin [ALB]\u2009&lt;\u200930\u2009g\/L) with 43 controls. Laryngoscopy assessed RE severity at baseline and after 6\u2009months. Patients with a smoking history, vocal abuse, hypothyroidism, or prior malignancy were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 6 months of follow\u2010up, the hypoalbuminemia group exhibited a significantly higher prevalence of RE compared to controls (24.4% vs. 7.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). Logistic regression confirmed hypoalbuminemia as an independent risk factor for RE (OR\u2009=\u20090.900,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). Receiver operating characteristic (ROC) analysis demonstrated that serum ALB levels predicted RE with an area under the curve (AUC) of 0.754 with an optimal cut\u2010off of 27.95\u2009g\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypoalbuminemia may be an independent etiological factor for RE, warranting vocal fold evaluation in chronic cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70170","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T07:03:01Z","timestamp":1759302181000},"page":"1392-1397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Hypoalbuminemia in the Development of Reinke's Edema: A Prospective Cohort Study"],"prefix":"10.1002","volume":"136","author":[{"given":"Xueshi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-3889","authenticated-orcid":false,"given":"Jilei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congli","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingguo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4492-0952","authenticated-orcid":false,"given":"Lihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"869","article-title":"Exudative Lesions of Reinke's Space: A Terminology Proposal","volume":"266","author":"Hantzakos A.","year":"2009","journal-title":"Otolaryngologic Clinics of North America"},{"key":"e_1_2_12_3_1","volume-title":"Reinke edema. 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