{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:41:25Z","timestamp":1791283285623,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The optimal treatment and timing for sudden sensorineural hearing loss (SSNHL) remain debated. This study aimed to determine if the hearing improvement and recovery time were better in the NAD+ group as compared to the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      There was a randomized, double\u2010blind, controlled clinical trial conducted between June 2022 and June 2024. SSNHL patients were randomly divided into two groups: the NAD+ group (NAD+ plus standard treatment,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918) and the control group (standard treatment,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920). The primary outcomes were PTA improvement, recovery rate per Siegel's criteria, and average recovery time, measured from baseline to 3\u2010month follow\u2010ups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study with 38 participants (average age 41.74\u2009years, 78.98% male, 42.11% right ear, average Pre\u2010PTA 76.88\u2009dB HL) showed that the NAD+ group experienced significantly greater hearing improvement (40.21\u2009dB HL) compared to the control group (23.06\u2009dB HL,\n                      <jats:italic>t<\/jats:italic>\n                      \u2009=\u20092.722,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). The effective rate was higher in the NAD+ group (94.44% vs. 60.00%,\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u2009\u22123.014,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Significant group\u2009\u00d7\u2009time interactions were noted in the NAD+ group (\n                      <jats:italic>F<\/jats:italic>\n                      \u2009=\u20092.867,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030), with greater improvements from 7\u2009days to 3\u2009months post\u2010treatment. Recovery time was shorter in the NAD+ group (62.97 vs. 175.98\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). Tinnitus and aural fullness improved more in the NAD+ group, especially after 3\u2009months. Higher pre\u2010treatment tinnitus and aural fullness scores were linked to better outcomes with NAD+ for SSNHL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NAD+ was more effective in improving hearing and reducing recovery time in SSNHL patients and also benefited tinnitus and aural fullness management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70173","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:55:42Z","timestamp":1759388142000},"page":"1204-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>NAD<\/scp>\n                    + Enhanced on 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Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Bao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-8539","authenticated-orcid":false,"given":"Yiqing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Institute of Hearing and Speech\u2010Language Science Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Hearing and Speech\u2010Language Science Guangzhou Xinhua University  Guangzhou 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