{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:57:05Z","timestamp":1792270625890,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AI151496"],"award-info":[{"award-number":["R21 AI151496"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG1 HL139126"],"award-info":[{"award-number":["UG1 HL139126"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UO1 AI123337"],"award-info":[{"award-number":["UO1 AI123337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Alcohol hypersensitivity (AH), an exacerbation of respiratory symptoms in response to alcohol consumption, is common in aspirin\u2010exacerbated respiratory disease (AERD) and other forms of chronic rhinosinusitis (CRS). The mechanism of this is unknown. This study investigates the ability of polyphenolic compounds in alcoholic beverages to activate innate immune cells as a means of explaining AH in AERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from 478 consecutive adults presenting to a tertiary care sinonasal clinic in whom the presence of AH and their CRS phenotype was determined. A subset of these individuals was invited to provide whole blood samples on which the effects of ethanol, red wine extract (RWE), and individual polyphenolic compounds were explored. Granulocyte activation was quantified by flow cytometry as upregulation of CD63 during the Basophil Activation Test (BAT). Additionally, secretion of lipid metabolites was measured by enzyme immunoassays (EIAs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve patients with CRSwNP were compared to age and sex\u2010matched healthy controls. A dose\u2010dependent stimulation of basophil degranulation was noted with RWE and epigallocatechin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No activation was noted in healthy controls or subjects to ethanol. Catechin demonstrated a dose\u2010dependent, but only near\u2010significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07) in basophil degranulation compared to controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Polyphenolic compounds, and not ethanol, can trigger the activation and degranulation of eosinophils and basophils, and this may explain the sensitivity to alcoholic beverages seen in patients with AERD and CRSwNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>NA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70183","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:41:34Z","timestamp":1760010094000},"page":"1126-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Polyphenolic Activation of Basophils Explains Alcohol Hypersensitivity in\n                    <scp>AERD<\/scp>"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-4561","authenticated-orcid":false,"given":"Spencer C.","family":"Payne","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"},{"name":"Division of Allergy &amp; Clinical Immunology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Eschenbacher","sequence":"additional","affiliation":[{"name":"Division of Allergy &amp; Clinical Immunology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Stepp","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Borish","sequence":"additional","affiliation":[{"name":"Division of Allergy &amp; Clinical Immunology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"issue":"416","key":"e_1_2_7_2_1","first-page":"249","article-title":"Mittheilun Uber Einen Fall von Nebenwirkun des Aspirin","volume":"28","author":"Hirschberg V. G. S.","year":"1902","journal-title":"Deutsche Medizinische Wochenschrift"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1911.02560170026012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-5-975"},{"key":"e_1_2_7_5_1","first-page":"189","article-title":"Anaphylaxie et idiosyncrasie","volume":"30","author":"Widal F.","year":"1922","journal-title":"Presse M\u00e9dicale"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.12.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.104548"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.05.003"},{"key":"e_1_2_7_9_1","first-page":"173","article-title":"5\u2010Hydroxytryptamine Release From Platelets by Different Red Wines: Implications for Migraine","volume":"292","author":"Pattichis K.","year":"1995","journal-title":"European Journal of Pharmacology"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.246"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.03.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.23078"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01305.x"},{"key":"e_1_2_7_15_1","first-page":"115","article-title":"Cardioprotection of Red Wine: Role of Polyphenolic Antioxidants","volume":"25","author":"Das D. 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