{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:14:23Z","timestamp":1773735263581,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Functional nasal surgery reliably alleviates nasal obstruction and improves quality of life. However, functional nasal surgery's effect on craniofacial pain (CFP) has been incompletely studied. This study analyzed CFP outcomes following functional nasal surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective cohort study was conducted with patients who underwent functional nasal surgery for nasal obstruction over 18\u2009months by two surgeons. Nasal Obstruction Symptom Evaluation (NOSE, 0\u201320) and facial pain scores (FPS, 0\u20135) were collected preoperatively and postoperatively. NOSE and FPS changes were compared between patients with FPS\u2009\u2265\u20092 versus FPS\u2009<\u20092 (i.e., with vs. without preoperative CFP).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 91 patients, mean age was 45.6\u2009years and 62.6% were male. Preoperatively, 36 patients had bothersome CFP, and 12\/36 (33.3%) had primary headache disorders. Preoperative mean FPSs were 3.2 and 0.2 for those with versus without preoperative FP, respectively. Mean durations to second and third postoperative visits were 47.7 and 203.1\u2009days, respectively. Across all patients, mean NOSE scores were significantly reduced at each follow\u2010up (\u22129.5,\n p<\/jats:italic>\n \u2009<\u20090.0001). Patients with preoperative CFP achieved significantly greater reductions in FPSs at second (\u22121.74 vs. +0.24,\n p<\/jats:italic>\n \u2009<\u20090.0001) and third (\u22122.20 vs. +0.04,\n p<\/jats:italic>\n \u2009<\u20090.0001) postoperative visits, and this was not affected by presence of headache disorders or allergic rhinitis (\n p<\/jats:italic>\n \u2009>\u20090.05). The relative risk (RR) of having FPS\u2009\u2265\u20092 was also significantly reduced at second (RR\u2009=\u20090.44,\n p<\/jats:italic>\n \u2009=\u20090.0002) and third (RR\u2009=\u20090.33,\n p<\/jats:italic>\n \u2009=\u20090.003) postoperative visits.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In patients with nasal obstruction and CFP preoperatively, functional nasal surgery led to significant improvements in both nasal obstruction and CFP, and these improvements persisted at about 6\u2009months postoperatively.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.70196","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:25:43Z","timestamp":1761071143000},"page":"1649-1655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Functional Nasal Surgery on Craniofacial Pain: A Prospective Cohort Study"],"prefix":"10.1002","volume":"136","author":[{"given":"John R.","family":"Craig","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Michigan State University College of Human Medicine Lansing Michigan USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Henry Ford Health Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeewanjot S.","family":"Grewal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Henry Ford Health Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Grossbauer","sequence":"additional","affiliation":[{"name":"Oakland University William Beaumont School of Medicine Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Henry Ford Health Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-9920","authenticated-orcid":false,"given":"Robert H.","family":"Deeb","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Michigan State University College of Human Medicine Lansing Michigan USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Henry Ford Health Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894221111254"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.16.1769"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.02.059"},{"issue":"7","key":"e_1_2_9_5_1","article-title":"Trigeminal Function in Sino\u2010Nasal Health and Disease","volume":"11","author":"Shusterman D.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.32164"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-12386-3_17"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024618"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22216"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23199"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21502"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24926"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1995.hed3507404.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100090812"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100098911"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139207100106"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6415.434"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1551"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900429"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29673"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1006908"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003139"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S490459"},{"issue":"9","key":"e_1_2_9_24_1","first-page":"1113","article-title":"Experimental Studies on Headache: Pain Originating in Nasal and Paranasal Structures","volume":"50","author":"McAuliffe G. 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