{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:27Z","timestamp":1779400647930,"version":"3.53.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1TR004405"],"award-info":[{"award-number":["UM1TR004405"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["5R01CA254270\u201002"],"award-info":[{"award-number":["5R01CA254270\u201002"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Oral potentially malignant disorders (OPMDs) are local and systemic conditions that can result in oral malignancies. We have had an OPMD surveillance program for 25\u2009years covering over 30% of our state's population. More recent electronic health record search techniques have allowed us to analyze over 1500 patients in over a 10\u2010year period, approximately 20% of total referrals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic health record (EHR) information was queried for 24 International Classification of Disease (ICD) 9 and 10 codes to generate a de\u2010identified data set. Charts within this data set were cross\u2010referenced against 79 ICD9\/10 codes corresponding to oral and oropharyngeal cancers. The time course of conversion and frequencies of precancerous and cancerous lesions was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 4496 unique patients seen, 1535 patient records met inclusion criteria. Seventy two patients showed cancerous conversion (4.69%), with 55 (3.58%) before 5\u2009years, and 17 (1.11%) after a 5\u2010year surveillance period. Leukoplakia and OLP patients constituted 34.7% of conversions, though other lesions\/diseases of the tongue\/oral mucosa showed conversion. Tongue cancers were the most represented carcinomas, followed by carcinomas of the oropharynx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We discovered overall rates of malignant conversion within the broad range reported in the world literature (0%\u201360%). Importantly, this living data set can be repeatedly queried over time to discover significant malignant conversions, potentially over decades. With significant conversions occurring after 5\u2009years, OPMD conditions likely require longer\u2010term surveillance like colon, breast, or other cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70199","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:25:25Z","timestamp":1761071125000},"page":"1755-1761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Analysis of Oral Potentially Malignant Disorder Conversion to Malignancy"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3471-3715","authenticated-orcid":false,"given":"Benjamin","family":"Palatnik","sequence":"first","affiliation":[{"name":"University of Minnesota Medical School\u2010Twin Cities  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Mortensen","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School\u2010Twin Cities  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr","family":"Palatnik","sequence":"additional","affiliation":[{"name":"Itec Engineering LLC  Pewaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly R.","family":"Wuertz","sequence":"additional","affiliation":[{"name":"Department\u00a0of Otolaryngology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-9335","authenticated-orcid":false,"given":"Frank G.","family":"Ondrey","sequence":"additional","affiliation":[{"name":"Department\u00a0of Otolaryngology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cancer Facts & Figures\u00a02025 1930."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.866"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197610)38:4<1790::AID-CNCR2820380456>3.0.CO;2-I"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.825266"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz238"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1980.tb01302.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1988.tb01528.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225740"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.22454\/FamMed.2018.372427"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/AMEP.S332797"},{"key":"e_1_2_10_15_1","first-page":"261","article-title":"New Hope for an Oral Cancer Solution: Together we Can Make a Difference","volume":"74","author":"Rosin M. 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