{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:14:04Z","timestamp":1773735244108,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Injection laryngoplasty is a common procedure to improve glottic closure following unilateral vocal fold paralysis (UVFP) or vocal fold atrophy. Allograft adipose matrix (AAM, Renuva, MTF Biologics) supports neoadipogenesis making it a potentially permanent solution. Given the known favorable properties of vocal fold lipoinjection, we hypothesize AAM to be a useful injection material with possible durable results following injection laryngoplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A prospective clinical trial of patients with UVFP underwent injection augmentation laryngoplasty with AAM. Blinded independent laryngologists and expert listeners used pretreatment and 3\u2010month postinjection videostroboscopy and CAPE\u2010V assessments to evaluate glottic closure, pliability and voice quality changes. Patient\u2010reported outcome measures (PROMs) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 21 patients underwent AAM injection; 16 had a diagnosis of unilateral vocal fold paralysis and were included for analysis. There were no adverse reactions. The raters observed an improvement in post\u2010treatment voice in 81.3% of cases, and CAPE\u2010V scores showed an average reduction of 32.3 points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). There was an average reduction in VHI\u201010 scores of 11.3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). The raters perceived the post\u2010AAM treatment videostroboscopy exams to be better in 68.8% of cases. Thirty\u2010seven percent of incomplete glottic closure was considered complete, and there was no change in pliability at 3\u2009months post\u2010AAM injection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study on AAM as an injection material in the vocal fold for augmentation laryngoplasty in unilateral vocal fold paralysis. It appears to be safe and effective on early follow\u2010up. Additional studies with longer follow\u2010up are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      <jats:bold>4<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70240","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:39:06Z","timestamp":1762429146000},"page":"1808-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Short\u2010Term Outcomes of Allograft Adipose Matrix (\n                    <scp>AAM<\/scp>\n                    ) for Vocal Fold Augmentation"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2734-3677","authenticated-orcid":false,"given":"Chloe","family":"Santa Maria","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0872-869X","authenticated-orcid":false,"given":"Elizabeth A.","family":"Shuman","sequence":"additional","affiliation":[{"name":"USC Voice Center, Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-8627","authenticated-orcid":false,"given":"Yael E.","family":"Bensoussan","sequence":"additional","affiliation":[{"name":"USF Health Voice Center, Department of Otolaryngology\u2010Head and Neck Surgery University of Southern Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neel K.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-9595","authenticated-orcid":false,"given":"Jake","family":"Morgan","sequence":"additional","affiliation":[{"name":"USC Voice Center, Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Rodman","sequence":"additional","affiliation":[{"name":"Southern California Clinical and Translational Science Institute (SC CTSI) University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kacie","family":"La Forest","sequence":"additional","affiliation":[{"name":"USC Voice Center, Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-217X","authenticated-orcid":false,"given":"Lauren","family":"Timmons\u2010Sund","sequence":"additional","affiliation":[{"name":"USC Voice Center, Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Michael M.","family":"Johns","sequence":"additional","affiliation":[{"name":"USC Voice Center, Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"O'Dell","sequence":"additional","affiliation":[{"name":"USC Voice Center, Department of Otolaryngology\u2010Head &amp; Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20945"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24740"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.117714"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2003.12.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.4.177"},{"key":"e_1_2_8_7_1","article-title":"Silk\u2010Hyaluronic Acid for Vocal Fold Augmentation: Safety Profile and Long\u2010Term Voice Outcomes","author":"Dwyer C. 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