{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:55:29Z","timestamp":1793418929274,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Red blood cell distribution width (RDW) predicts surgical success in adult patients undergoing open airway reconstruction for laryngotracheal stenosis, but similar biomarkers in pediatrics remain unidentified. This study identifies predictors of outcomes in pediatric patients undergoing triple endoscopy or surgical airway reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of 191 pediatric patients who underwent triple endoscopy or surgical airway reconstruction at an aerodigestive center between 4\/18\/2013 and 4\/17\/2023 was completed. Ninety\u2010eight patients with lab values within 2\u2009months of the procedure were included. Main outcome measures were prosthesis\u2010free breathing at last follow\u2010up, hospitalization length, and follow\u2010up duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lower RDW values were associated with prosthesis\u2010free breathing at last follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042) and shorter hospitalizations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Higher monocyte\u2010to\u2010lymphocyte ratio (MLR) and systemic inflammation response indexes (SIRI) correlated with increased length of hospitalization (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and tracheomalacia were associated with longer follow\u2010up periods (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Patients with tracheomalacia and OSA prior to intervention were more likely to require tracheostomy at last follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RDW may predict long\u2010term surgical success and outcomes in pediatric patients with complex airway, pulmonary, and upper digestive tract disorders. Serologic markers including SIRI, MLR, NLR, and PLR may also predict outcomes. Patient demographics and surgical type did not correlate with long\u2010term outcomes, but patients with tracheomalacia and OSA were more likely to require tracheostomy at later time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70241","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:39:46Z","timestamp":1764311986000},"page":"1920-1927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory Markers Stratify Surgical Outcomes in Pediatric Airway Reconstruction"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-5088","authenticated-orcid":false,"given":"Nomongo","family":"Dorjsuren","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-2430","authenticated-orcid":false,"given":"Hrithik","family":"Praveen","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1349-7005","authenticated-orcid":false,"given":"Kalpnaben","family":"Patel","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Center for Kids (SOCKs) Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3921-3965","authenticated-orcid":false,"given":"Shilin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Center for Kids (SOCKs) Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0078-1305","authenticated-orcid":false,"given":"Alexander","family":"Gelbard","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Monroe Carell Junior Children's Hospital at Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9189-6353","authenticated-orcid":false,"given":"Christopher","family":"Wootten","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Monroe Carell Junior Children's Hospital at Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.3057"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1658"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537\u2010200101000\u201000009"},{"issue":"4","key":"e_1_2_8_5_1","first-page":"308","article-title":"Complications of Endotracheal Intubation and Other Airway Management Procedures","volume":"49","author":"Divatia J. 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