{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:13:51Z","timestamp":1773735231832,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the pressure\u2010volume (P\u2010V) behavior of two common endotracheal tube (ETT) cuffs across three airway models of increasing anatomic realism: rigid, elastic, and cadaveric, and to quantify the narrow volume threshold separating safe from potentially injurious cuff pressures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We tested TaperGuard and Sheridan reinforced ETTs (sizes 6.0\u20138.0\u2009mm) in a rigid manikin, elastic synthetic, and cadaveric tracheas. Cuff pressure was recorded after 0.2\u2009mL incremental inflation up to 120 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O. Polynomial and power\u2010law models were fitted to the P\u2010V curves. Key metrics included \u0394V from 20 to 30 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O, curve slope, and model fit accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All cuffs demonstrated nonlinear P\u2010V behavior. Cadaveric tracheas exhibited the steepest pressure escalation, with \u0394V (20\u2009\u2192\u200930 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O) as small as 0.25\u2009mL. Elastic models showed delayed pressure rise, while rigid models escalated rapidly once wall contact was reached. Polynomial models (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009\u2265\u20090.93\u20130.99) better captured high\u2010pressure transitions than power\u2010law fits. Tapered cuffs achieved effective seals with lower volumes than cylindrical cuffs but demonstrated similarly steep pressure increases when overinflated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ETT cuff behavior is highly sensitive to airway compliance. Cadaveric airways showed a narrower inflation margin than synthetic models, underscoring the limitations of manikin\u2010based training. Across designs, small additional volumes can precipitate unsafe pressures, highlighting the need for precise pressure\u2010guided cuff management over volume estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70245","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T11:30:15Z","timestamp":1766230215000},"page":"1822-1829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Endotracheal Tube Cuff Pressure\u2010Volume in Simulated and Cadaveric Tracheas"],"prefix":"10.1002","volume":"136","author":[{"given":"Alexandria","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amila","family":"Niksic","sequence":"additional","affiliation":[{"name":"Swanson School of Engineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Affolter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605241275884"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2011661"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181f2ecc7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1468310"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6422.965"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01812"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104\u20100630OC"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab724"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5935\/1678\u20109741.20140096"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102334\u201014\u2010119"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010016\u20101380\u20108"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.11.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9567"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03799"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq202"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.87.6.720"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02683"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10903127.2015.1061626"},{"issue":"6","key":"e_1_2_9_20_1","first-page":"443","article-title":"A Comparison of Endotracheal Tube Cuff Pressures Using Estimation Techniques and Direct Intracuff Measurement","volume":"71","author":"Stewart S. L.","year":"2003","journal-title":"AANA Journal"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.920726"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012702"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038326"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010017\u20104736\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2006.07.535"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102923.2009.03547.x"},{"issue":"3","key":"e_1_2_9_27_1","first-page":"137","article-title":"Linear Correlation of Endotracheal Tube Cuff Pressure and Volume","volume":"10","author":"Hoffman R. J.","year":"2009","journal-title":"Western Journal of Emergency Medicine"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/qhc.13.suppl_1.i11"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.12809\/hkmj133930"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/eje.12522"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T06:01:55Z","timestamp":1773727315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,20]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/lary.70245"],"URL":"https:\/\/doi.org\/10.1002\/lary.70245","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,20]]},"assertion":[{"value":"2025-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}