{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:15:22Z","timestamp":1773735322565,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze risk factors for Laryngeal Web (LW) formation following CO2 laser surgery combined with topical photodynamic therapy (T\u2010PDT) in patients with recurrent respiratory papillomatosis (RRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed RRP patients treated with CO2 laser surgery combined with T\u2010PDT at a single academic medical center between January 2021 and April 2024. The Cohen grading system was used to assess laryngeal web severity before and after treatment. The Wilcoxon rank\u2010sum test was performed to compare pre\u2010 and post\u2010treatment adhesion scores. Univariate and multivariate logistic regression analyses were conducted to identify risk factors for LW formation, including gender, surgical age, onset age, HPV genotype, lesion distribution (Derkay score), preoperative LW presence, previous surgical history, bilateral involvement, and preoperative bevacizumab treatment within 1 month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 86 RRP patients received CO2 laser surgery combined with T\u2010PDT treatment. Post\u2010treatment LW occurred in 23.26% (20\/86) of patients. No significant difference was observed in Cohen grading distribution between pre\u2010 and post\u2010treatment groups (\n                      <jats:italic>W<\/jats:italic>\n                      \u2009=\u2009226.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.934). Multivariate analysis identified preoperative LW presence (OR\u2009=\u20098.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) as an independent risk factor for post\u2010treatment LW formation, whereas preoperative bevacizumab treatment was associated with a lower risk of LW formation (OR\u2009=\u20090.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CO2 laser surgery combined with T\u2010PDT demonstrated a relatively low incidence of LW formation in RRP treatment. Preoperative LW presence significantly increased the risk of post\u2010treatment LW formation, while preoperative bevacizumab treatment was associated with a lower risk of LW formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70251","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:04:57Z","timestamp":1762283097000},"page":"1866-1871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Influencing Laryngeal Web After Surgery Combined With Photodynamic Therapy in\n                    <scp>RRP<\/scp>"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5005-3108","authenticated-orcid":false,"given":"Yufei","family":"Pan","sequence":"first","affiliation":[{"name":"School of Medicine Southeast University  Nanjing Jiangsu China"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Nanjing Medical Key Laboratory of Laryngopharynx\u2010Head &amp; Neck Oncology  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9658-4177","authenticated-orcid":false,"given":"Huili","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Nanjing Medical Key Laboratory of Laryngopharynx\u2010Head &amp; Neck Oncology  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Nanjing Medical Key Laboratory of Laryngopharynx\u2010Head &amp; Neck Oncology  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2792-5711","authenticated-orcid":false,"given":"Huiying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Nanjing Medical Key Laboratory of Laryngopharynx\u2010Head &amp; Neck Oncology  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-6758","authenticated-orcid":false,"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Nanjing Medical Key Laboratory of Laryngopharynx\u2010Head &amp; Neck Oncology  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0470-8240","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Nanjing Medical Key Laboratory of Laryngopharynx\u2010Head &amp; Neck Oncology  Nanjing Jiangsu 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