{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:13:39Z","timestamp":1777976019740,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To assess whether elexacaftor\u2013tezacaftor\u2013ivacaftor (ETI) reduces the frequency of endoscopic sinus surgeries (ESS) in patients with cystic fibrosis (pwCF).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a retrospective chart review of pwCF aged 6\u2009years and older who received ETI between January 1, 2018 and December 31, 2023. Inclusion criteria required a history of ESS and a follow\u2010up time of at least 2\u2009years before and after ETI initiation. Records were reviewed from up to 8\u2009years prior to ETI through the most recent visit. The total number and frequency of ESS were evaluated using univariable linear models, estimating mean difference with 95% confidence intervals (CI) and\n p<\/jats:italic>\n \u2010values.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fifty\u2010six patients met inclusion criteria, with a median follow\u2010up time of 8\u2009years (IQR: 8, 8) before ETI initiation and 4.13\u2009years (IQR: 3.47, 4.78) after initiation of ETI. Median age at ETI initiation was 13\u2009years (IQR: 10, 23). Among these patients, 98% (\n n<\/jats:italic>\n \u2009=\u200955) required ESS prior to ETI, compared to 21% (\n n<\/jats:italic>\n \u2009=\u200912) after ETI. The average number of sinus surgeries decreased from 2.88\u2009\u00b1\u20091.68 before ETI to 0.30\u2009\u00b1\u20090.63 after ETI (mean difference: 2.6; 95% CI: [2.1, 3.1];\n p<\/jats:italic>\n \u2009<\u20090.001). The frequency of surgeries per year dropped from 0.37\u2009\u00b1\u20090.22 to 0.07\u2009\u00b1\u20090.15 after beginning ETI (mean difference: 0.30; 95% CI: [0.23, 0.37];\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n ETI was associated with a significant decrease in the frequency and rate of ESS in pwCF. These findings suggest an improvement in CF\u2010related chronic rhinosinusitis outcomes following ETI and may influence future CF treatment decisions.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 4.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.70283","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T12:09:27Z","timestamp":1764850167000},"page":"2048-2053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elexacaftor\u2013Tezacaftor\u2013Ivacaftor Reduces Revision Sinus Surgery in People With Cystic Fibrosis"],"prefix":"10.1002","volume":"136","author":[{"given":"Amy","family":"Lin","sequence":"first","affiliation":[{"name":"The Ohio State University College of Medicine Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makanko","family":"Komara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Kistler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nationwide Children's Hospital Columbus Ohio USA"},{"name":"Center for Biostatistics the Ohio State University Wexner Medical Center Columbus Ohio USA"},{"name":"Biostatistics Resource at Nationwide Children's Hospital Abigail Wexner Research Institute at Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-464X","authenticated-orcid":false,"given":"Zheng Hong","family":"Tan","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Lind","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine Columbus Ohio USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"Kotha","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine Columbus Ohio USA"},{"name":"Department of Pulmonary Sleep Medicine and Cystic Fibrosis, Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1448-5873","authenticated-orcid":false,"given":"Tendy","family":"Chiang","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Medicine Columbus Ohio USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11060589"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32542\u20103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12180"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.04.013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20106749(92)90183\u20103"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010021\u201005576\u2010z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211046719"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"e_1_2_9_10_1","volume-title":"FDA approves new breakthrough therapy for cystic 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