{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:30:36Z","timestamp":1794241836878,"version":"4.9.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To critically evaluate clinical and voice\u2010related outcomes of in\u2010office serial intralesional steroid injection (SILSI) in adults diagnosed with idiopathic subglottic stenosis (iSGS).<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n \n MEDLINE, Embase, CINAHL Ultimate, CENTRAL,\n ClinicalTrials.gov<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Review Methods<\/jats:title>\n A systematic search of databases was conducted from inception through April 5, 2025. Studies eligible for inclusion must have reported on adult SILSI recipients undergoing management of iSGS. Articles were independently screened and reviewed by two authors for treatment variables including steroid protocol, clinical outcomes, respiratory function, vocal outcomes, and complications.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 383 studies identified, 14 met inclusion criteria (\n n<\/jats:italic>\n \u2009=\u2009371). Triamcinolone was the most commonly used agent in 10 studies. Steroid dosage, number of treatment sessions, and injection interval varied widely across studies. Improvements in surgery\u2010free interval, peak expiratory flow, dyspnea index, degree of stenosis, and voice\u2010related outcomes were observed in several studies. No major complications were reported in the included studies.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Current evidence suggests SILSI represents a promising adjunctive therapy in the treatment of iSGS, with improvement noted across several measures. However, significant variability in steroid treatment regimens and inconsistent reporting of outcomes complicate interpretations of efficacy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.70300","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T11:29:40Z","timestamp":1765020580000},"page":"2018-2025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In\u2010Office Steroid Injections for Idiopathic Subglottic Stenosis: A Systematic Review"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2522-4408","authenticated-orcid":false,"given":"Eric","family":"Delgado Rendon","sequence":"first","affiliation":[{"name":"Florida State University College of Medicine Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawfal","family":"Saleem","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine Bradenton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1114-4904","authenticated-orcid":false,"given":"Natalie","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head & Neck Surgery Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-6328","authenticated-orcid":false,"given":"Amy","family":"Rutt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head & Neck Surgery Mayo Clinic Jacksonville Florida 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