{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:13:55Z","timestamp":1778922835174,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Lindsay\u2010Hemenway syndrome (LHS) is characterized by an acute unilateral vestibular loss followed by ipsilateral posterior semicircular canal (PSC) benign paroxysmal positional vertigo (BPPV). Despite its clinical relevance, comparative data between LHS, isolated acute unilateral vestibulopathy (AUVP), and idiopathic PSC BPPV are uncommon. This work aims to compare vestibular function and clinical outcomes in patients diagnosed with LHS, isolated AUVP, and idiopathic PSC BPPV.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A multicenter longitudinal study was conducted between 2018 and 2025, enrolling 98 patients divided into three groups: LHS (\n n<\/jats:italic>\n \u2009=\u200936), isolated AUVP (\n n<\/jats:italic>\n \u2009=\u200930), and idiopathic PSC BPPV (\n n<\/jats:italic>\n \u2009=\u200932). Vestibular evaluation was assessed through video head impulse test (vHIT), evaluation of spontaneous nystagmus, and Dix\u2010Hallpike maneuver. Primary outcomes included vestibular gain at baseline and 6\u2009months, presence and characteristics of corrective saccades, number of repositioning maneuvers required, and time to symptom resolution.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with LHS showed significantly greater initial vestibular impairment in both affected and contralateral ears compared to isolated AUVP (\n p<\/jats:italic>\n \u2009<\u20090.05) and demonstrated slower functional recovery at 6\u2009months. Saccade amplitude was notably larger in LHS patients (\n p<\/jats:italic>\n \u2009<\u20090.05), while latency and clustering were similar across groups. Spontaneous nystagmus persisted more frequently in the LHS cohort (OR 3.67). All LHS patients developed ipsilateral PSC BPPV, which required more repositioning maneuvers (\n p<\/jats:italic>\n \u2009<\u20090.043) and presented a longer clinical course than idiopathic PSC BPPV (\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Lindsay\u2010Hemenway syndrome involves more severe vestibular dysfunction, slower recovery, and more persistent BPPV than isolated AUVP or idiopathic PSC BPPV.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 3<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.70324","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:32:02Z","timestamp":1766475122000},"page":"2701-2707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lindsay\u2010Hemenway Syndrome, Acute Vertigo Followed by\n BPPV<\/scp>\n : A Prospective Comparative Study"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5823-9175","authenticated-orcid":false,"given":"Paula Morales","family":"Chacchi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University Hospital of Getafe Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo Coronel","family":"Touma","sequence":"additional","affiliation":[{"name":"Otoneurology Unit. ENT Deparment. University Hospital of Salamanca. IBSAL. Surgery Department. University of Salamanca Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Cabrera","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Otoneurology Unit. ENT Deparment. University Hospital of Salamanca. IBSAL. Surgery Department. University of Salamanca Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-670X","authenticated-orcid":false,"given":"\u00c1ngel","family":"Batuecas\u2010Caletr\u00edo","sequence":"additional","affiliation":[{"name":"Otoneurology Unit. ENT Deparment. University Hospital of Salamanca. IBSAL. Surgery Department. University of Salamanca Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-3844","authenticated-orcid":false,"given":"Eduardo Martin","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospital of Getafe Madrid Spain"},{"name":"Department of Medicine, School of Biomedical Sciences and Health Universidad Europea de Madrid Villaviciosa de Od\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348945606500311"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"1","article-title":"Vestibular Neuritis","volume":"90","author":"Schuknecht H. F.","year":"1981","journal-title":"Annals of Otology, Rhinology, and Laryngology. Supplement"},{"issue":"8","key":"e_1_2_9_4_1","first-page":"599","article-title":"Ischemia of the Anterior Vestibular Artery (Lindsay\u2010Hemenway Syndrome)","volume":"49","author":"Pardal Refoyo J. L.","year":"1998","journal-title":"Acta Otorrinolaringol\u00f3gica Espa\u00f1ola"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000041081"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319871234"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309128074"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.06.905"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-220201"},{"issue":"6","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.otorri.2017.02.007","article-title":"Benign Paroxysmal Positional Vertigo: Diagnostic Criteria Consensus Document of the Committee for the Classification of Vestibular Disorders of the B\u00e1r\u00e1ny Society","volume":"68","author":"Brevern M.","year":"2017","journal-title":"Acta Otorrinolaringologica Espa\u00f1ola (English Edition)"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903311278"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.593551"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000169787.99835.9f"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp021154"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.3.755"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2484-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1241037"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-N1543"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-200703"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164801750388171"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1127008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221503762624521"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-1549"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000004512"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.14201\/orl.21022"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2025-00030"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2023.22703"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70324","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:47:12Z","timestamp":1778921232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/lary.70324"],"URL":"https:\/\/doi.org\/10.1002\/lary.70324","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}