{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:14:12Z","timestamp":1777976052308,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Head and neck squamous cell carcinoma (HNSCC) lacks reliable prognostic circulating biomarkers, and the role of the immune system in its progression remains incompletely understood. This study aimed to evaluate the prognostic value of systemic inflammatory and immune biomarkers in surgically treated patients with primary oral cavity (OCSCC) or laryngeal squamous cell carcinoma (LSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010center study included 394 patients with OCSCC or LSCC who underwent surgery with curative intent. Preoperative blood samples were analyzed to assess platelet, neutrophil, lymphocyte, and monocyte counts, as well as T\u2010cell subpopulations (CD3+, CD4+, and CD8+). Composite ratios\u2014including neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), lymphocyte\u2010to\u2010monocyte ratio (LMR), and systemic immune\u2010inflammation index (SII)\u2014were evaluated for their correlation with global (GR), local (LR), and distant (DR) recurrence risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Univariate analysis identified elevated platelet counts, PLR, SII, and neutrophil levels as significantly associated with increased GR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0014,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0058 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016, respectively) and LR risk, with the exception of neutrophil levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0072, respectively). In contrast, higher CD4+\/CD3+ (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038) and CD4+\/CD8+ (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) ratios were associated with reduced DR risk. Multivariate analysis confirmed platelet count as an independent predictor for GR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001) and LR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002), while a high CD4+\/CD8+ ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) was independently protective against DR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight the prognostic relevance of platelet\u2010related inflammatory markers and circulating T\u2010cell ratios in recurrence risk among HNSCC patients. The differential associations with local versus distant recurrence underscore the complex interplay between systemic inflammation and adaptive immunity. Prospective validation is warranted to confirm these biomarkers' utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70334","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T09:36:08Z","timestamp":1766482568000},"page":"2189-2198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting Different Recurrence Risk in\n                    <scp>HNSCC<\/scp>\n                    Using Circulating Inflammatory and T\u2010Cell Biomarkers"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8347-0463","authenticated-orcid":false,"given":"Riccardo","family":"Gili","sequence":"first","affiliation":[{"name":"Medical Oncology, Department of Internal Medicine and Medical Specialties University of Genova  Genoa Italy"},{"name":"Department of Medical Oncology UO Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Lovino","family":"Camerino","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2010Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Lalli","sequence":"additional","affiliation":[{"name":"Unit of Translational Immunology IRCCS Foundation National Cancer Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0957-8354","authenticated-orcid":false,"given":"Elisa","family":"Bellini","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2010Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2010Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo Bruno","family":"Lanza","sequence":"additional","affiliation":[{"name":"Medical Oncology, Department of Internal Medicine and Medical Specialties University of Genova  Genoa Italy"},{"name":"Department of Medical Oncology UO Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology UO Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Radiology Unit IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Peretti","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology\u2010Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Del Mastro","sequence":"additional","affiliation":[{"name":"Medical Oncology, Department 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