{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:14:18Z","timestamp":1773735258072,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013928","name":"Dysphonia International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Botulinum toxin A (BtxA) injection for AdLD is typically performed approxiamately every 3\u2009months. DaxibotulinumtoxinA\u2010lanm (Daxi) is a peptide\u2010formulated neuromodulator with reported longer therapeutic duration. This study compared the safety and efficacy of Daxi to historical BtxA results in AdLD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this open\u2010label, prospective clinical trial, 22 stable\u2010dose, BtxA\u2010responsive AdLD patients underwent Daxi injection. To optimize safety, the first 10 patients' doses were given in a staged fashion (3\u20136\u2009days between half doses). Safety and duration of voice benefit (DVB) were the primary outcomes. PROMs and voice analyses were obtained pre\u2010 and monthly post\u2010injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 22 patients, 20 (75% female, mean age\u2009=\u200958.3) were analyzed, with two excluded for injection \u201cmisses.\u201d No adverse reactions were reported. EAT\u201010 showed no difference pre\u2010 and post\u2010Daxi injection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.068). VHI\u201010 significantly improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) pre\u2010 to post\u2010injection. Procedural LEMG quantitative data for Daxi and BtxA were comparable (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.279). DVB of Daxi was longer than BtxA in 8\/20 (40%), equal to BtxA in 7\/20 (35%), and shorter than BtxA in 5\/19 (25%). Those with Daxi benefit had on average 43.9% (39.5\u2009days) longer therapeutic duration than previous BtxA treatments. Seven patients (35%) returned to BtxA at subsequent injection whereas 13 patients (65%) desired repeat Daxi injection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study represents the first implementation of Daxi for AdLD. Daxi was notably safe and effective. Although no overall significant difference was noted for the entire study cohort, 40% of patients reported substantially longer duration of voice benefit with Daxi than with BtxA, with 43.9% longer duration than their previous BtxA treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70353","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T08:25:48Z","timestamp":1767428748000},"page":"1830-1837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing\n                    <scp>DaxibotulinumtoxinA<\/scp>\n                    to\n                    <scp>OnabotulinumtoxinA<\/scp>\n                    for Adductor Laryngeal Dystonia: A Pilot Study"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3878-0974","authenticated-orcid":false,"given":"Alexandra D.","family":"D'Oto","sequence":"first","affiliation":[{"name":"UCSF Voice &amp; Swallowing Center, Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6215-4853","authenticated-orcid":false,"given":"Claire E.","family":"Perrin","sequence":"additional","affiliation":[{"name":"UCSF Voice &amp; Swallowing Center, Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camryn R.","family":"Marshall","sequence":"additional","affiliation":[{"name":"UCSF Voice &amp; Swallowing Center, Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-8290","authenticated-orcid":false,"given":"VyVy N.","family":"Young","sequence":"additional","affiliation":[{"name":"UCSF Voice &amp; Swallowing Center, Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvi","family":"Rawat","sequence":"additional","affiliation":[{"name":"UCSF Voice &amp; Swallowing Center, Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5748-0976","authenticated-orcid":false,"given":"Desi","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"UCSF Voice &amp; Swallowing Center, Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Schneider","sequence":"additional","affiliation":[{"name":"UCSF Voice &amp; Swallowing Center, Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0872-869X","authenticated-orcid":false,"given":"Elizabeth A.","family":"Shuman","sequence":"additional","affiliation":[{"name":"USC Voice Center, Department of Otolaryngology\u2010Head and Neck Surgery Keck School of Medicine  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-1086","authenticated-orcid":false,"given":"Clark A.","family":"Rosen","sequence":"additional","affiliation":[{"name":"UCSF Voice &amp; 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