{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:17:15Z","timestamp":1778923035576,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AG057832"],"award-info":[{"award-number":["K23AG057832"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010836","name":"American Laryngological, Rhinological and Otological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Previous studies have examined the relationship between dysphonia and mental health, but often in small samples and not across age groups. In this large national epidemiological study, we examine if dysphonia is related to anxiety and depression generally and across cohorts of different ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross\u2010sectional analysis of adults\u2009\u2265\u200918\u2009years old in the All of Us dataset. The exposure was dysphonia (ICD\u201010 code R49.0), and the outcomes were anxiety (ICD\u201010 F41) and depression (ICD\u201010 F32\u201033). We performed multivariable logistic regression analyses, controlling for age, gender, race, ethnicity, insurance, education, smoking history, alcohol use, and medical comorbidities. A sub\u2010analysis compared depression and anxiety odds across two and five age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 283,137 adults in our sample, the mean age was 56\u2009years (standard deviation 16\u2009years). Sixty\u2010one percent identified as female. Controlling for covariates, those with dysphonia had 1.34 times (95% CI 1.27\u20131.41) the odds of depression and 1.44 times (1.37\u20131.52) the odds of anxiety compared to their non\u2010dysphonia counterparts. After stratifying by age, the odds of depression and anxiety were 2.36 times (1.67\u20133.35) and 1.62 (1.14\u20132.30) respectively for participants \u2265\u200918\u201330\u2009years old, 1.61 (1.37\u20131.89) and 1.75 (1.49\u20132.07) for &gt;\u200930\u201345\u2009year olds, 1.38 (1.23\u20131.55) and 1.46 (1.33\u20131.67) for &gt;\u200945\u201360\u2009year olds, 1.33 (1.23\u20131.44) and 1.46 (1.35\u20131.58) for &gt;\u200960\u201375\u2009year olds, and 1.22 (1.09\u20131.35) and 1.36 (1.22\u20131.51) for &gt;\u200975\u2009year olds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Those with dysphonia had higher odds of depression and anxiety. Following stratification by age, the odds for each were highest for the youngest age group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70372","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:36:46Z","timestamp":1768883806000},"page":"2648-2654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dysphonia Is Associated With Anxiety and Depression in the\n                    <scp>A<\/scp>\n                    ll\n                    <scp>o<\/scp>\n                    f\n                    <scp>U<\/scp>\n                    s\n                    <scp>R<\/scp>\n                    esearch\n                    <scp>P<\/scp>\n                    rogram"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-4654","authenticated-orcid":false,"given":"Hannah N. W.","family":"Weinstein","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons, NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-5997","authenticated-orcid":false,"given":"Michael W.","family":"Denham","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3247-6515","authenticated-orcid":false,"given":"Lauren H.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons, NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin S.","family":"Golub","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons, NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley L.","family":"Born","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Columbia University Vagelos College of Physicians and Surgeons, NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"StatPearls","author":"Neighbors C.","year":"2025"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"S1","article-title":"Clinical Practice Guideline: Hoarseness (Dysphonia) (Update)","volume":"158","author":"Stachler R. 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