{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:02:31Z","timestamp":1781143351193,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["RS\u20102024\u201000461726"],"award-info":[{"award-number":["RS\u20102024\u201000461726"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["RS\u20102025\u201002243112"],"award-info":[{"award-number":["RS\u20102025\u201002243112"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023443","name":"Commercializations Promotion Agency for R and D Outcomes","doi-asserted-by":"publisher","award":["RS\u20102025\u201002222568"],"award-info":[{"award-number":["RS\u20102025\u201002222568"]}],"id":[{"id":"10.13039\/501100023443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence and characteristics of objectively confirmed laryngopharyngeal reflux (LPR) in patients with laryngeal contact granuloma (LCG) using 24\u2010h hypopharyngeal\u2013esophageal multichannel intraluminal impedance\u2013pH (HEMII\u2010pH) monitoring, and to compare patient and disease features by reflux status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients diagnosed with LCG who underwent 24\u2010h HEMII\u2010pH monitoring. Reflux episodes were classified by acidity (acid, weakly acidic, weakly alkaline) and posture (upright, recumbent). Clinical characteristics, reflux episode profiles, lesion laterality, and Reflux Symptom Index (RSI) scores were compared between reflux\u2010positive and reflux\u2010negative patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 41 patients, 25 (61.0%) were reflux\u2010positive and 16 (39.0%) were reflux\u2010negative, with no hypopharyngeal reflux event detected. The pH\u2010based classification of reflux events identified a predominance of weakly acidic (46.2%) and weakly alkaline (44.3%) episodes; acidic events were uncommon (9.5%). Most reflux events occurred during upright periods (94.8%), with only 5.2% during recumbent position. Among unilateral lesions, a higher proportion of hypopharyngeal reflux\u2010positive cases involved the left side (76.2% left, 23.8% right), while reflux\u2010negative cases showed no lateral preference (60.0% left, 40.0% right). Symptom screening with the RSI had limited discrimination for hypopharyngeal reflux status (sensitivity 50.0%, specificity 46.7%, PPV 60.0%, NPV 36.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight the limitations of symptom\u2010based diagnosis and empiric acid suppression in patients with LCG. Pre\u2010treatment 24\u2010h HEMII\u2010pH monitoring can provide a more evidence\u2010based initial approach than routine empiric therapy and supports individualized behavioral interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70407","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:44:04Z","timestamp":1769766244000},"page":"3053-3058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Objective Assessment of Laryngopharyngeal Reflux in Laryngeal Contact Granuloma"],"prefix":"10.1002","volume":"136","author":[{"given":"Hyun Jee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Kyung Hee University School of Medicine Kyung Hee University Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yup","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Kyung Hee University School of Medicine Kyung Hee University Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Kyung Hee University School of Medicine Kyung Hee University Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-7288","authenticated-orcid":false,"given":"Young Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Kyung Hee University School of Medicine Kyung Hee University Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Gyu","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Korean Medicine Kyung Hee University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-5207","authenticated-orcid":false,"given":"Young\u2010Gyu","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery, Kyung Hee University School of Medicine Kyung Hee University Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199910000-00008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000504"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139707600606"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i8.1989"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30976"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31134"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06865-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2022.07.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2020.11.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-07201-w"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08436-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2023.10.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28736"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998211029831"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10023-1224"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14015430903150210"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2019.11.019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-4783"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm21235"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.799"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2024.02.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2019.01669"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1372"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:30:02Z","timestamp":1781141402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/lary.70407"],"URL":"https:\/\/doi.org\/10.1002\/lary.70407","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}