{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:02:37Z","timestamp":1781143357562,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203132"],"award-info":[{"award-number":["82203132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230034"],"award-info":[{"award-number":["82230034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373016"],"award-info":[{"award-number":["82373016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373407"],"award-info":[{"award-number":["82373407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471134"],"award-info":[{"award-number":["82471134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82261160399"],"award-info":[{"award-number":["82261160399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Postradiation nasopharyngeal necrosis (PRNN) is one of the most severe and famous complications after radiotherapy for nasopharyngeal carcinoma (NPC). Resurfacing with pedicle nasal floor\u2010nasal septum muco\u2010periosteal flap after PRNN debridement is important and effective. However, the flap is limited for recovering large lesions like the parapharyngeal space and cervical vertebra. Here, we introduced a pedicle inferior turbinate\u2010nasal floor and septal mucoperiosteal flap (inferior turbinate\u2010nasal flap, ITNF) for reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From November 2012 to July 2025, 71 PRNN patients with necrosis involving the parapharyngeal space or extensive skull base received endoscopic nasopharyngeal necrosis debridement followed by ITNF resurfacing were enrolled and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All surgeries were successfully performed without any severe postoperative complications or death. The 3\u2010month complete healing and effective healing rate achieved 69.0% and 98.5%. The 1\u2010 and 2\u2010year overall survival (OS) rate of the entire cohort reached 87.3% and 81.7%, respectively. The degree of necrosis was identified as an independent predictor of complete nasopharyngeal defect healing (OR\u2009=\u200919.520, 95% CI: 2.335\u2013163.156,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). It was also found to be an independent predictor of OS (HR\u2009=\u200910.443, 95% CI: 1.312\u201383.116,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ITNF resurfacing after endoscopic debridement is a safe, effective, and promising treatment for PRNN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70430","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:03:13Z","timestamp":1773028993000},"page":"2971-2978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pedicled Inferior Turbinate\u2010Nasal Floor and Septal Mucoperiosteal Flap Resurfacing for\n                    <scp>PRNN<\/scp>"],"prefix":"10.1002","volume":"136","author":[{"given":"Yu\u2010Tong","family":"Liu","sequence":"first","affiliation":[{"name":"Nasopharyngeal Cancer Center The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai China"},{"name":"Guangdong Provincial Research Center for Early Detection and Treatment of Nasopharyngeal Carcinoma  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng\u2010Yu","family":"Ren","sequence":"additional","affiliation":[{"name":"Nasopharyngeal Cancer Center The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai China"},{"name":"Guangdong Provincial Research Center for Early Detection and Treatment of Nasopharyngeal Carcinoma  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Di","family":"Yuan","sequence":"additional","affiliation":[{"name":"Nasopharyngeal Cancer Center The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai China"},{"name":"Guangdong Provincial Research Center for Early Detection and Treatment of Nasopharyngeal Carcinoma  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Qian","family":"Song","sequence":"additional","affiliation":[{"name":"Nasopharyngeal Cancer Center The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai China"},{"name":"Guangdong Provincial Research Center for Early Detection and Treatment of Nasopharyngeal Carcinoma  Zhuhai 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Kai","family":"Feng","sequence":"additional","affiliation":[{"name":"Nasopharyngeal Cancer Center The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai China"},{"name":"Guangdong Provincial Research Center for Early Detection and Treatment of Nasopharyngeal Carcinoma  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Nasopharyngeal Cancer Center The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai China"},{"name":"Guangdong Provincial Research Center for Early Detection and Treatment of Nasopharyngeal Carcinoma  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Qi","family":"Long","sequence":"additional","affiliation":[{"name":"Nasopharyngeal Cancer Center The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai 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