{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:02:07Z","timestamp":1789826527626,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate epidemiological associations between the development of adult chronic rhinosinusitis (CRS) and treatment with surgery or biologic therapy following pediatric adenotonsillectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a multicenter, retrospective cohort study utilizing data from 100 healthcare organizations in the United States. The TriNetX database identified adults older than 18\u2009years with or without prior childhood tonsillectomy and\/or adenoidectomy. Outcomes included CRS without nasal polyposis (CRSsNP), with nasal polyposis (CRSwNP), sinus surgery, and biologic therapy. Subgroup analysis of patients with childhood obstructive sleep apnea (OSA), recurrent\/chronic tonsillitis, adenoiditis, or middle ear disease was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no statistically significant difference in the rate of adult CRSsNP, CRSwNP, surgery, and treatment with biologics after pediatric adenotonsillectomy for childhood OSA (HR: 0.94 [0.87\u20131.02]; 1.07 [0.79\u20131.44]; 0.87 [0.59\u20131.28]; 0.85 [0.66\u20131.09]). Children who had an adenoidectomy alone had a higher rate of CRSsNP as adults (HR: 1.55 [1.30\u20131.85]). Surgery for tonsillitis and adenoiditis had a higher rate of CRSwNP and surgery (HR: 1.63 [1.21\u20132.32]; 1.97 [1.36\u20132.86]). Adenoidectomy for adenoiditis was associated with CRSsNP (HR: 1.94 [1.73\u20132.19]). Adults with pediatric middle ear disease who had a childhood adenoidectomy alone had an increased rate of CRSsNP (HR: 1.47 [1.30\u20131.65]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tonsillectomy with adenoidectomy in the setting of specific childhood infectious diseases was associated with adult CRSwNP and the need for sinus surgery, whereas adenoidectomy was associated with CRSsNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70451","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:30:43Z","timestamp":1771475443000},"page":"3381-3390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of Adult Chronic Rhinosinusitis With Pediatric Tonsillectomy and Adenoidectomy"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6408-3077","authenticated-orcid":false,"given":"Robert E.","family":"Africa","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2257-4721","authenticated-orcid":false,"given":"Brian J.","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold S.","family":"Pine","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusif","family":"Hajiyev","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Hardison","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2013.04.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.1.7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815623467"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814549302"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818801757"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0614"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16184"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201089553\u20101"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.924"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.05.014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.26327"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31774"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau3776"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20105876(02)00009\u20105"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1287"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201069981\u20101"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509139388"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137876"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.061"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103038.2007.00630.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2023.2181391"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29506"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.09.038"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abk2189"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaw036"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9378"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.02.016"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.1344"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12759"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29527"}],"container-title":["The 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