{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:08:21Z","timestamp":1793203701855,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the diagnostic value of preoperative hematologic inflammatory indices in distinguishing benign from malignant parotid gland tumors and to assess their potential as adjunctive diagnostic tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included 259 patients who underwent parotidectomy at the Department of Otorhinolaryngology, Necmettin Erbakan University Faculty of Medicine, from January 2020 to January 2025. Demographic data, histopathologic diagnoses, and preoperative parameters were reviewed. Inflammatory indices (NLR, PLR, SII, SIRI, WMR, and NP\/LHb) were calculated. Comparative analyses among pleomorphic adenoma, Warthin's tumor, and malignant tumors were performed using one\u2010way ANOVA, Kruskal\u2013Wallis, and post hoc tests. Receiver operating characteristic (ROC) analysis was used to determine discriminative performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 259 patients, 101 had pleomorphic adenoma, 107 had Warthin tumor, and 51 had malignant tumors. Warthin tumors demonstrated significantly higher white blood cell, neutrophil, lymphocyte, monocyte, and hemoglobin levels than both pleomorphic adenoma and malignant tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Malignant tumors were associated with older age, larger tumor size and volume, higher NLR and PLR values, and lower lymphocyte, monocyte, and hemoglobin levels (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). ROC analysis identified age (cut\u2010off: 60.5\u2009years; AUC\u2009=\u20090.642) and tumor volume (cut\u2010off: 24.75\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      ; AUC\u2009=\u20090.664) as the strongest predictors of malignancy. An NLR cut\u2010off value of 1.62 yielded 86% sensitivity and 31% specificity for differentiating malignant from benign lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative hematologic indices\u2014NLR and PLR\u2014may serve as inexpensive, accessible adjunctive tools in evaluating parotid masses. Integration of inflammatory indices into radiomics\u2010based or nomogram\u2010driven diagnostic models has the potential to improve diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>N\/A<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70491","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:51:14Z","timestamp":1774324274000},"page":"3783-3790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Systemic Inflammatory Markers in Predicting Malignancy in Parotid Gland Tumors"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-4652","authenticated-orcid":false,"given":"Ozcelik Erdem","family":"Rukiye","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Necmettin Erbakan University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9912-2152","authenticated-orcid":false,"given":"Yegin","family":"Onur","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Necmettin Erbakan University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-969X","authenticated-orcid":false,"given":"Ery\u0131lmaz Mehmet","family":"Akif","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Necmettin Erbakan University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6146-8801","authenticated-orcid":false,"given":"Arbag","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Necmettin Erbakan 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.106052"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.11.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201005868\u20101"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27061"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14041342"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201006298\u20109"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.06.018"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894251348373"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22392"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061876"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.52"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.09.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju124"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00207"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00096"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S195413"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/19160216251364761"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13565"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2024.102087"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201097499\u2010x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1392343"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.5455\/annalsmedres.2021.04.331"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2025.100854"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.5152\/cjms.2021.2718"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816659257"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17081373"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.31878"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14051762"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.947334"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2025.2554650"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.05.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13154574"}],"container-title":["The 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