{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T02:08:54Z","timestamp":1783908534151,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence and clinical relevance of labyrinthine abnormalities detected by delayed 3D FLAIR MRI in untreated otosclerosis with labyrinthine symptoms, and to evaluate correlations with clinical and audiometric data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective observational study, single tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010four patients (58 ears) with confirmed otosclerosis by high\u2010resolution CT presenting with labyrinthine symptoms and no prior surgery underwent 3T labyrinthine MRI with a post\u2010contrast delayed 3D FLAIR sequence. Two blinded neuroradiologists independently reviewed CT to confirm otosclerotic and MRI to assess endolymphatic space anomalies and blood\u2013labyrinth barrier (BLB) disruption. Findings were correlated with clinical symptoms and bone\u2010conduction thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Otosclerotic foci most frequently involved the pre\u2010stapedial region (57\/58, 98%). Morphological anomalies of the endolymph were rare, with one case of endolymphatic hydrops (1\/58, 2%). In contrast, BLB disruption was identified in 34\/58 ears (59%), predominantly in the basal cochlear turn (34\/58, 59%) and peri\u2010saccular region (32\/58, 55%). BLB disruption was strongly associated with endosteal involvement (76%) and round window involvement (89%), and was universally present in obliterative round window involvement (100%). Its prevalence increased with hearing loss type (55% in conductive, 66% in mixed, and 100% in pure sensorineural hearing loss). However, no significant correlation was found between BLB intensity and bone\u2010conduction thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endolymphatic hydrops was rare in untreated otosclerosis with labyrinthine symptoms. Conversely, BLB disruption was frequent in this symptom\u2010select population, spatially correlated with otosclerotic foci, reflecting underlying microvascular remodeling. While not directly predictive of hearing thresholds, BLB disruption may represent an imaging biomarker of disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70506","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:13:18Z","timestamp":1774325598000},"page":"3559-3568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Labyrinthine Abnormalities on\n                    <scp>MRI<\/scp>\n                    in Untreated Otosclerosis: Prevalence and Clinical Relevance"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6232-0909","authenticated-orcid":false,"given":"H\u00e9l\u00e9na","family":"Pencroffi","sequence":"first","affiliation":[{"name":"Neuroradiology Department Hospital Fondation Adolphe de Rothchild  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Bourdoncle","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Hospital Fondation Adolphe de Rothchild  Paris France"},{"name":"Neuroradiology Department Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Fanet","sequence":"additional","affiliation":[{"name":"ENT\u2010HRS Department Hospital Fondation Adolphe de Rothchild  Paris France"},{"name":"ENT\u2010HRS Department Toulouse Universit\u00e9 Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-4210","authenticated-orcid":false,"given":"St\u00e9phane","family":"Gargula","sequence":"additional","affiliation":[{"name":"ENT\u2010HRS Department Hospital Fondation Adolphe de Rothchild  Paris France"},{"name":"ENT\u2010HRS Department, Aix Marseille University, APHM La Conception University Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Ayache","sequence":"additional","affiliation":[{"name":"ENT\u2010HRS Department Hospital Fondation Adolphe de Rothchild  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Duron","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Hospital Fondation Adolphe de Rothchild  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Savatovsky","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Hospital Fondation Adolphe de Rothchild  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Poillon","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Hospital Fondation Adolphe de Rothchild  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Aure Humana Tractacus Bonosiac","author":"Valsalva A.","year":"1704"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.11.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.11.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000276627"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0022215100050933"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537\u2010197404000\u201000012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454036"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u2010119x.1000308"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20934"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2020.03.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509139303"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198408000-00001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196\u20100709(94)90068\u2010x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000685"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002175"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318298ac96"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0221\u20100363(06)74157\u20109"},{"issue":"2","key":"e_1_2_10_19_1","first-page":"81","article-title":"Reliability of CT Scan in the Diagnosis of Conductive Hearing Loss With Normal Tympanic Membrane","volume":"122","author":"Shin Y. 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