{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T02:08:55Z","timestamp":1783908535850,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Surgical repair and 3D\u2010printed customized septal prosthesis (3D\u2010PCSP) are options for septal perforation treatment. We performed a study to compare the clinical outcomes of surgery and 3D\u2010PCSP using the NOSE\u2010Perf Scale (NPfS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A chart review was performed on patients undergoing surgical repair or 3D\u2010PCSP placement between January 2018 and July 2024. The change in NPfS was used as primary endpoint. Demographics, ASA score, perforation size, etiology, and follow\u2010up duration were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five patients, 23 for surgical repairs and 12 for 3D\u2010PCSP, were included in this review [median (IQR)]. In the surgical repair group, perforation length and height measured 12 (10\u201318) mm and 10 (8\u201315) mm, respectively. Baseline NPfS was 24 (16\u201332), and this decreased to 8 (6\u201313) following surgical repair (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Follow\u2010up time was 12 (5\u201321) months. In the 3D\u2010PCSP group, septal perforation length and height measured 25 (15\u201330) mm and 17 (15\u201320) mm, respectively. The baseline NPfS was 17 (3\u201324.5), and this decreased to 9.5 (7\u201313) following 3D\u2010PCSP placement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The follow\u2010up was 18.4 (16\u201323) months. NPfS reduction was greater for surgical repair (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgery and 3D\u2010PCSP offer meaningful symptom relief for NSP patients. Treatment decisions should be individualized through shared decision\u2010making that considers patient comorbidities, preferences, surgeon experience, and risk tolerance. In this cohort, surgical repair was associated with greater NPfS reduction compared with 3D\u2010PCSP placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70508","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:14:17Z","timestamp":1773796457000},"page":"3452-3457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptom Outcomes After Septal Perforation Surgical Repair Versus\n                    <scp>3D<\/scp>\n                    \u2010Printed Customized Prosthesis"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6422-5271","authenticated-orcid":false,"given":"Pedro Lan\u00e7a","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic in Arizona  Phoenix Arizona USA"},{"name":"Graduate Program in Medical Sciences Universidade de Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-9254","authenticated-orcid":false,"given":"Nitish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic in Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Bansberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic in Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-0310","authenticated-orcid":false,"given":"Michael J.","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic in Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-2385","authenticated-orcid":false,"given":"Devyani","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic in Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Miglani","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic in Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882\u2010018\u20100754\u20101"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30299"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.01.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2023.103916"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4324"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29901"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000857"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894231183497"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599821992010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.31329"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2011.44"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.918"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894221098704"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpsam.2021.0421"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347\u20109264.2023.109"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70508","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:47:36Z","timestamp":1783907256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/lary.70508"],"URL":"https:\/\/doi.org\/10.1002\/lary.70508","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"2025-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}