{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T02:08:57Z","timestamp":1783908537819,"version":"3.55.0"},"reference-count":109,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Surgery is the definitive treatment for most thyroid cancers. However, anaplastic thyroid carcinoma (ATC) and other undifferentiated thyroid cancers are often unresectable and carry high mortality. Case reports and series have described neoadjuvant therapies, including chemotherapy, targeted therapy, radiation, and radioactive iodine, to improve resectability. This review evaluates the efficacy and safety of neoadjuvant therapy in unresectable thyroid cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed, Embase, and Web of Science.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was performed through August 2025 following PRISMA\u2010ScR guidelines. English\u2010language studies reporting patient\u2010specific data on thyroid cancer diagnosis and neoadjuvant treatment were included. Using Covidence, patient demographics, neoadjuvant therapies, surgical interventions, and outcomes were extracted from 87 studies following inclusion and exclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individual patient data were available for 122 patients from 61 studies. The most common cancers were papillary thyroid carcinoma (PTC), ATC, and differentiated thyroid carcinoma (DTC). The median age was 61\u2009years, 54% female. TNM staging was 68% T4, 69% N1, and 51% M0. Frequent mutations included BRAFV600E (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200931), RET (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200918), TERT (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200912), and TP53 (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200912). Lenvatinib (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200946) and dabrafenib and trametinib (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200926) were the most used. Total thyroidectomy occurred in 53% of patients. Post\u2010neoadjuvant therapy outcomes included partial response (64%) and complete response (10%), with subsequent R0 (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200962), R1 (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200938), and R2 (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200910) surgical resections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neoadjuvant therapy shows promise in improving resectability for unresectable and poorly differentiated thyroid cancers, with 51% of patients achieving R0 resection. Future studies should investigate optimal therapy selection, timing, dosing, and long\u2010term outcomes, including disease\u2010specific survival and patient\u2010reported measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>NA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70531","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:45:22Z","timestamp":1774961122000},"page":"3335-3360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoadjuvant Therapies for Thyroid Cancer: A Scoping Review"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9532-249X","authenticated-orcid":false,"given":"Ava","family":"Herzog","sequence":"first","affiliation":[{"name":"Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishan","family":"Patel","sequence":"additional","affiliation":[{"name":"Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Leyden","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn","family":"Preece","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Lahey","sequence":"additional","affiliation":[{"name":"Schaffer Library of Health Sciences Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Gildener\u2010Leapman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"NIH \u201cCancer Stat Facts: Thyroid Cancer. 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