{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:08:46Z","timestamp":1789186126255,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR001415"],"award-info":[{"award-number":["TL1TR001415"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To observe the incidence of Meniere's disease (MD) and MD\u2010related symptoms (i.e., aural fullness, tinnitus, hearing loss, and vertigo) between (a) non\u2010migraine and migraine patients and (b) migraine untreated and migraine treated patients within the TriNetX database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of (a) non\u2010migraine and migraine patients and (b) migraine treated and untreated patients within the TriNetX database from 2013 till 2025. Patients underwent propensity score matching for sex, age, race, and known lifestyle\/disease confounders for MD. Incidence of MD and MD\u2010related symptoms were evaluated 5\u2009years post index date and beyond 5\u2009years post index date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Migraine patients demonstrated a greater incidence of MD and MD\u2010related symptoms 5\u2009years and more than 5\u2009years post index date. Amongst migraine patients, those not receiving treatment demonstrated a lesser predilection (risk ratio [RR]\u2009=\u20090.43, 95% CI: 0.28\u20130.66) of developing MD than patients receiving treatment. There was no significant difference in the incidence of hearing loss or aural fullness between migraine untreated and treated subgroups. Migraine patients not receiving treatment had an increased risk of experiencing tinnitus (RR\u2009=\u20091.11, 95% CI: 1.03\u20131.19).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There exists a connection between migraine and MD. Migraine patients receiving migraine treatment are statistically significantly more likely to develop MD compared to non\u2010migraine patients. These results support the findings of preceding studies that have demonstrated a pathophysiological link between migraine and vestibulocochlear dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70578","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:00:37Z","timestamp":1776830437000},"page":"4424-4432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Meniere's Disease and Migraine: Effect of Migraine Medications on Symptoms of Meniere's Disease"],"prefix":"10.1002","volume":"136","author":[{"given":"Khushi","family":"Bhatt","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Rara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2270-5207","authenticated-orcid":false,"given":"Hamid R.","family":"Djalilian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  Irvine California USA"},{"name":"Department of Biomedical Engineering University of California  Irvine California USA"},{"name":"Department of Neurological Surgery University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-698X","authenticated-orcid":false,"given":"Mehdi","family":"Abouzari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"S1","article-title":"Clinical Practice Guideline: M\u00e9ni\u00e8re's Disease","volume":"162","author":"Basura G. 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