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Hundred patients were randomized to receive either add\u2010on OM\u201085 (34\/50) or control group (43\/50); 77 participants completed the 12\u2010month follow\u2010up. The OM\u201085 group received oral treatment for 10\u2009days, followed by a 20\u2010day washout (Months 1\u20133 and 7\u20139). Primary outcome was the PR rate. Secondary outcomes included PROMs, Lund\u2010Kennedy (L\u2010K) scores, Lund\u2010Mackay (L\u2010M) scores, and complete blood count (CBC) parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PR rate was significantly lower in the OM\u201085 group (8.82%) than in the control group (27.91%,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20094.408,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036). Univariable analysis identified pre\u2010operative Lund\u2010Mackay (L\u2010M) score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and hyposmia VAS score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) as significant predictors of PR. In multivariable analysis, the L\u2010M score remained an independent predictor (OR\u2009=\u20091.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), with an optimal cutoff of 10. The OM\u201085 group showed significant improvements in nasal obstruction, olfactory dysfunction, and mucopurulent discharge at 6 and 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Lund\u2010Kennedy (L\u2010K) score and 22\u2010item Sinonasal Outcome Test (SNOT\u201022) score were also significantly improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Furthermore, the OM\u201085 group exhibited elevated white blood cell counts and lymphocyte percentages from 6\u2009months onward (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjuvant OM\u201085 may reduce postoperative PR, with improved endoscopic and symptom scores, potentially mediated by enhanced systemic immune function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70581","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:34:42Z","timestamp":1777286082000},"page":"4189-4197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bacterial Lysates Add\u2010On Therapy to Reduce Postoperative Recurrence in Nasal Polyps"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-5351","authenticated-orcid":false,"given":"Huiyi","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 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