{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:46:03Z","timestamp":1792053963273,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hypoxia\u2010related measures are valuable predictors of cardiovascular outcomes in obstructive sleep apnea. This scoping review evaluates existing literature on changes in hypoxia\u2010related measures with hypoglossal nerve stimulation (HGNS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>A systematic search was performed across PubMed, Embase, Web of Science, and Scopus databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>\n                      Population search terms included HGNS and upper airway stimulation. Measures of interest included hypoxic burden, oxygen desaturation index (ODI), and time below 90% or 88% oxygen saturation (T90\/T88). Title, abstract, and full\u2010text screenings were conducted by two reviewers. Studies that only reported O\n                      <jats:sub>2<\/jats:sub>\n                      nadir or mean were excluded. When multiple studies were based on the same cohort of HGNS patients, the manuscript with the most comprehensive oxygenation measures was included; if these did not differ, the one with the longest period of follow\u2010up was used. Postoperative sleep studies were labeled as titration polysomnography (PSG), full\u2010night PSG at a single voltage, unspecified PSG type, or home sleep test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 581 articles were identified, 86 underwent full\u2010text review, and 22 studies corresponding to\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092092 patients met inclusion criteria. There was heterogeneity in sleep testing types across studies. ODI was included in 20 studies (90.9%) and T90\/T88 in 13 (59.1%). The majority of studies (15 of 17) demonstrated significant improvement in ODI from pre\u2010 to post\u2010HGNS, but not in T90\/T88. No studies meeting inclusion criteria reported hypoxic burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The available literature suggests improvements in hypoxia\u2010related measures with HGNS, though most report frequency\u2010based measures and there is a dearth of literature examining HGNS and hypoxic burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70638","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:29:26Z","timestamp":1780032566000},"page":"4692-4702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Hypoxia\u2010Related Metrics With Hypoglossal Nerve Stimulation: A Scoping 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