{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:46:00Z","timestamp":1792053960428,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Recurrence of chronic rhinosinusitis (CRS) after endoscopic sinus surgery (ESS) is common; however, biomarkers for long\u2010term risk stratification remain limited. We examined associations between complete blood count (CBC)\u2010derived biomarkers and long\u2010term CRS recurrence after ESS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort of 543 CRS patients undergoing ESS was analyzed using time\u2010to\u2010event methods. Prespecified variables comprised CBC\u2010derived biomarkers: absolute eosinophil count (AEC); eosinophil\u2010to\u2010lymphocyte, \u2010monocyte, and \u2010neutrophil ratios; monocyte\u2010, neutrophil\u2010, basophil\u2010, and platelet\u2010to\u2010lymphocyte ratios; systemic immune\u2010inflammation index (SII); systemic inflammation response index; and red cell distribution width, together with prespecified clinical covariates. Variable selection was performed using LASSO\u2010penalized Cox regression with multicollinearity screening, followed by multivariable Cox modeling to estimate adjusted hazard ratios (HRs). Incremental prognostic value and longitudinal patterns were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 254 patients (46.8%) developed recurrence. In the multivariable model, higher AEC (HR: 2.868) and SII (HR: 1.320) were associated with recurrence, along with shorter symptom duration, asthma, NSAID hypersensitivity, nasal polyps, and higher Lund\u2013Mackay scores. Addition of AEC improved model discrimination (\n                      <jats:italic>C<\/jats:italic>\n                      \u2010index 0.778\u20130.797; \u0394\n                      <jats:italic>C<\/jats:italic>\n                      \u2009=\u20090.019;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas SII provided minimal additional value (\n                      <jats:italic>C<\/jats:italic>\n                      \u2010index 0.797\u20130.798; \u0394\n                      <jats:italic>C<\/jats:italic>\n                      \u2009=\u20090.001;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.513). In longitudinal analyses, baseline AEC and SII were associated with recurrence, but their changes over time did not differ between groups, with no significant temporal trends.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher AEC and SII were independently associated with long\u2010term CRS recurrence after ESS, with AEC providing greater incremental prognostic value than SII. These markers may reflect underlying host predisposition rather than dynamic disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70647","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:44:05Z","timestamp":1780047845000},"page":"4744-4754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CBC<\/scp>\n                    \u2010Derived Biomarkers Associated With Recurrence After Sinus Surgery in Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-8975","authenticated-orcid":false,"given":"Virat","family":"Kirtsreesakul","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramee","family":"Thongsuksai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuttha","family":"Sanghan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakapan","family":"Promsopa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"issue":"29","key":"e_1_2_11_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens W. 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