{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:25:48Z","timestamp":1783599948566,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Despite the prevalence of neurogenic chronic cough (NCC), treatment options remain limited. This study investigates selective laryngeal cryotherapy (SLC) as a potential sensory neurolytic therapy. The primary objective was to explore the feasibility and safety of SLC, while the secondary objectives assessed efficacy in the reduction of laryngeal hypersensation and cough symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with refractory NCC were prospectively recruited. Patients underwent laryngeal laser sensory testing (LST), immediately followed by awake SLC treatment. Cough measures including the cough severity index (CSI) and urge to cough visual analog scale (UTC\u2010VAS) were collected at baseline and regular intervals. At 1\u2010month postprocedure, additional LST was performed. Safety, tolerability, and adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty patients with NCC were enrolled. All patients successfully completed awake SLC. There were no serious adverse events or unanticipated adverse device effects. 21% of patients experienced at least one treatment\u2010emergent adverse event, all of which self\u2010resolved within 2\u2009days. Post\u2010SLC patients had a higher mean laser power threshold, 7.5\u2009W (SD 2.42) to trigger a cough response compared to their baseline threshold of 2.8\u2009W (SD 2.76) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). By 6 months, patients demonstrated sustained improvement compared to their baseline, with a reduction in CSI of \u22128.25 (95% CI 11.60, \u22124.91) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and UTC\u2010VAS \u221218.07 (95% CI \u221229.71, \u22126.43) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The data suggest that awake laryngeal cryotherapy is feasible, tolerable, and safe. SLC reduced laryngeal hypersensitivity, and while it is a promising treatment option for neurogenic cough, further research is required to confirm its long\u2010term effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70723","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:47:07Z","timestamp":1783597627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laryngeal Cryotherapy for Neurogenic Cough: Safety, Feasibility, and Prospective Outcomes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9873-8641","authenticated-orcid":false,"given":"Shumon I.","family":"Dhar","sequence":"first","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Lun","family":"Liu","sequence":"additional","affiliation":[{"name":"O'Donnell School of Public Health University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3878-0974","authenticated-orcid":false,"given":"Alexandra D.","family":"D'Oto","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2014Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Suresh","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-9360","authenticated-orcid":false,"given":"Adrianna","family":"Shembel","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Speech, Language and Hearing, School of Behavioral and Brain Sciences University of Texas at Dallas  Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-6707","authenticated-orcid":false,"given":"Ted","family":"Mau","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2014Head &amp; Neck Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.975"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15\u20101496"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.09.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.07.022"},{"key":"e_1_2_10_7_1","unstructured":"M. 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