{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:46:00Z","timestamp":1792053960720,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Prospectively evaluate longitudinal voice changes in transmasculine adolescents and young adults (AYAs) initiating testosterone therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      AYAs assigned female sex at birth and na\u00efve to testosterone and voice therapy were prospectively enrolled prior to hormone initiation and followed for 12\u2009months. Fundamental frequency (\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      ) during sustained vowel and connected speech, pitch range, and cepstral peak prominence smooth (CPPs) were measured monthly. Patient\u2010reported outcome measures analyzed include VHI\u201010, Transgender Voice Questionnaire (TVQ), and PROMIS Anxiety and Depression scales.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen individuals enrolled; 14 (mean age [SD]\u2009=\u200918.43\u2009years [4.31]) completed 12\u2010month follow\u2010up for analysis. Speaking\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      decreased at 3\u2009months (mean \u221232.9\u2009Hz,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) and plateaued by 9\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Sustained vowel\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      decreased earlier at 2\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036). Semi\u2010tone pitch range showed no significant change across 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.47). CPPs in connected speech decreased significantly from baseline at 3\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and improved but remained significantly lower than baseline at nine (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). VHI\u201010 transiently worsened at 3\u2009months (+3.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) but returned to baseline by 9\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.42). TVQ improved significantly from baseline (51.3) to 12\u2009months (26.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). PROMIS Anxiety decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018), while Depression did not (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.56).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Testosterone therapy in transmasculine AYAs results in progressive lowering of\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      beginning at Month 2 and stabilizing by Month 9, with improved voice\u2010gender congruence and anxiety. This is the first prospective study with a substantial adolescent cohort, providing critical data that strengthens understanding of testosterone\u2010related voice changes and informs best practices in gender\u2010affirming voice care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70729","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T01:35:45Z","timestamp":1786152945000},"page":"4945-4956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Effects of Testosterone on Voice in Transmasculine Adolescents and Young Adults"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1758-3276","authenticated-orcid":false,"given":"Yue","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-4292","authenticated-orcid":false,"given":"Nikhil","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James","family":"Lappin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Walch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology University of California San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpreet Kaur","family":"Khalsa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco School of Medicine  San Francisco California 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