{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:46:06Z","timestamp":1792053966786,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze tracheal specimens obtained during tracheotomy in patients with prolonged intubation and investigate the relationship between intubation duration and the development of histopathological damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010six adult patients undergoing surgical tracheotomy were categorized into three groups based on intubation duration: 7\u201314\u2009days (Group A), 15\u201328\u2009days (Group B), and \u2265\u200929\u2009days (Group C). The control group comprised 20 patients with laryngeal cancer who underwent laryngectomy and tracheotomy. Tracheal specimens obtained during routine procedures were subjected to histopathological evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant differences were observed between the intubated groups and the control group in terms of ulceration, inflammatory cell infiltration, granulation tissue formation, microabscess formation, dilatation, neovascularization, desmoplasia, degeneration, perichondritis, and calcification. The incidence of dilatation and perichondritis increased significantly with longer intubation duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prolonged endotracheal intubation is associated with various histopathological changes in the trachea. Given that histopathological injury and complication rates increase with intubation duration, performing tracheotomy within the first 14\u2009days may be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70753","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:46:29Z","timestamp":1784166389000},"page":"4858-4865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Intubation Duration on Trachea: A Histopathological Study"],"prefix":"10.1002","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5352-1035","authenticated-orcid":false,"given":"Osman","family":"Kilic","sequence":"first","affiliation":[{"name":"ENT Clinic G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-1547","authenticated-orcid":false,"given":"Serdal","family":"Celik","sequence":"additional","affiliation":[{"name":"ENT Clinic G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital  \u0130stanbul T\u00fcrkiye"},{"name":"Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery \u0130stanbul Medeniyet University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-923X","authenticated-orcid":false,"given":"Cemal","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology Medicana International Istanbul Hospital  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4612-3071","authenticated-orcid":false,"given":"Berina","family":"Slipcevic","sequence":"additional","affiliation":[{"name":"ENT Clinic G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital  \u0130stanbul T\u00fcrkiye"},{"name":"Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery \u0130stanbul Medeniyet University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-6947","authenticated-orcid":false,"given":"Ayse Yasemin","family":"Gunduz","sequence":"additional","affiliation":[{"name":"ENT Clinic G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital  \u0130stanbul T\u00fcrkiye"},{"name":"Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery \u0130stanbul Medeniyet University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1434-789X","authenticated-orcid":false,"given":"Hamdi Sirac","family":"Gundogdu","sequence":"additional","affiliation":[{"name":"ENT Clinic G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital  \u0130stanbul T\u00fcrkiye"},{"name":"Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery \u0130stanbul Medeniyet University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-5467","authenticated-orcid":false,"given":"M. Tayyar","family":"Kalcioglu","sequence":"additional","affiliation":[{"name":"ENT Clinic G\u00f6ztepe Prof. Dr. S\u00fcleyman Yalcin City Hospital  \u0130stanbul T\u00fcrkiye"},{"name":"Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery \u0130stanbul Medeniyet University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.74160"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2015.03.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728\u2010200105000\u201000011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.68.3.340"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2018.01.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010017\u20104838\u20107"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010018\u20102126\u20106"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221075610"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000150026.85210.13"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp\u20102024\u2010002434"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14091165"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd\u201019\u20103716"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900807"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/00031348231160829"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/1012\u20105574.133218"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.10.049"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276\u2010002\u20100031\u20108"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20106576.1979.tb01422.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.109738"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70753","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:09:39Z","timestamp":1792051779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/lary.70753"],"URL":"https:\/\/doi.org\/10.1002\/lary.70753","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}