{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:44:21Z","timestamp":1785735861974,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Temperature\u2010controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve is a minimally invasive treatment for chronic rhinitis. While early studies show short\u2010term efficacy, long\u2010term durability remains unclear. This study evaluated the short\u2010 and long\u2010term efficacy and safety of TCRF neurolysis across discrete follow\u2010up intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>PubMed\/MEDLINE, Embase, and the Cochrane Library were searched from inception to March 2026.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>Following PRISMA 2020 guidelines (PROSPERO: CRD420261345320), studies evaluating adults undergoing TCRF neurolysis for chronic rhinitis with quantitative outcomes were included. Random\u2010effects meta\u2010analyses pooled outcomes at 3\u2009months, 6\u2009months, 12\u2009months, 2\u2009years, and 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies (924 patients) were included. TCRF neurolysis significantly reduced total nasal symptom scores (rTNSS) across all intervals: 3\u2009months (\u22123.96, 95% CI \u22124.26 to \u22123.67), 6\u2009months (\u22124.50, 95% CI \u22124.91 to \u22124.09), 12\u2009months (\u22124.70, 95% CI \u22125.04 to \u22124.37), 2\u2009years (\u22125.06, 95% CI \u22125.67 to \u22124.44), and 3\u2009years (\u22124.59, 95% CI \u22125.00 to \u22124.19). Symptom responder rates (\u2265\u200930% improvement) rose from 74% at 3\u2009months to 81%\u201384% during long\u2010term follow\u2010up. Mini Rhinoconjunctivitis Quality of Life Questionnaire scores demonstrated sustained improvements up to 3\u2009years. Adverse events were infrequent, minor, and transient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TCRF neurolysis provides safe, clinically meaningful, and durable improvements in nasal symptoms and quality of life for up to 3\u2009years, offering a robust therapeutic option for medically refractory chronic rhinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70763","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:48:45Z","timestamp":1785732525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiofrequency Neurolysis of the Posterior Nasal Nerve: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-9824","authenticated-orcid":false,"given":"Eyad","family":"Jamileh","sequence":"first","affiliation":[{"name":"School of Medicine, Queen's University Belfast  Belfast UK"},{"name":"Royal Blackburn Teaching Hospital; East Lancashire Hospitals Trust  Blackburn UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Muhammad","sequence":"additional","affiliation":[{"name":"School of Medicine, Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Xamza","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadijah","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine Southend University Hospital  Westcliff\u2010on\u2010Sea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Physics Leyton Sixth Form College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/108854190778879765"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.12.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.01.031"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.4.212"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/s002221511900166x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211033400"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X211041124"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30911"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010023\u201008242\u2010z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_12_1","unstructured":"E.JamilehandF.Muhammad \u201cShort\u2010 and Long\u2010Term Outcomes of Temperature\u2010Controlled Radiofrequency Neurolysis of the Posterior Nasal Nerve for Chronic Rhinitis: A Systematic Review and Meta\u2010Analysis. Prospero \u201d2026 https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420261345320."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2196\/64016"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010020\u201000238\u20108"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/21526575221096045"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924221109987"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924251360889"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23047"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23315"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23577"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1040"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1286"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613241285134"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613251382759"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.70101"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04481.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.23822\/eurannaci.1764\u20101489.268"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.70763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.70763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:48:52Z","timestamp":1785732532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.70763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":27,"alternative-id":["10.1002\/lary.70763"],"URL":"https:\/\/doi.org\/10.1002\/lary.70763","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]},"assertion":[{"value":"2026-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"lary.70763"}}