{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:59:13Z","timestamp":1785387553262,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy of non\u2010surgical organ\u2010preservation strategies for locally advanced or resectable laryngeal and hypopharyngeal squamous cell carcinoma (SCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Randomized controlled trials (RCTs) published through June 30, 2025, identified via systematic database and trial\u2010registry searches and reference screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and Bayesian random\u2010effects network meta\u2010analysis of RCTs enrolling adults with locally advanced\/resectable laryngeal\/hypopharyngeal SCC. Treatments included surgery plus postoperative radiotherapy (RT), RT alone, concurrent cisplatin\u2010based chemoradiotherapy (CTRT), induction chemotherapy followed by RT\/CTRT, altered\u2010fractionation RT, dose\u2010modified CTRT, and RT\u2009\u00b1\u2009cetuximab. Effect estimates were synthesized as hazard ratios (HRs) and odds ratios (ORs). Treatments were ranked using surface under the cumulative ranking curve (SUCRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094395; 13 strategies) were included. For laryngeal preservation, cisplatin\u2010based CTRT ranked highest (SUCRA 0.73), followed by induction TPF\u2009\u2192\u2009RT (0.72) and RT\u2009+\u2009cetuximab (0.61). All non\u2010surgical strategies outperformed surgery plus postoperative RT for laryngeal preservation (HR 0.34; 95% CI, 0.20\u20130.58). For overall survival, induction PF\u2009\u2192\u2009RT showed the highest probability of benefit (SUCRA 0.68), with overlapping credible intervals across leading regimens. For locoregional control, induction TPF\u2009\u2192\u2009RT ranked best (SUCRA 0.94). Sensitivity analyses supported robustness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Concurrent cisplatin\u2010based CTRT remains the most consistent organ\u2010preservation strategy. Induction PF\u2009\u2192\u2009RT may offer modest overall survival benefit, whereas sequential TPF\u2009\u2192\u2009RT appears superior for locoregional control. Treatment should be individualized by comorbidity, functional goals, and institutional expertise; head\u2010to\u2010head trials and incorporation of immunotherapy\/targeted agents are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70780","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:19:15Z","timestamp":1785385155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Locally Advanced Layngohypopharyngeal Cancers: A Network Meta\u2010Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-0449","authenticated-orcid":false,"given":"Vincenzo","family":"Capriotti","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit Portogruaro Hospital  Portogruaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-1004","authenticated-orcid":false,"given":"Elisa Dal","family":"Cin","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Head and Neck Department Mestre Hospital  Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostina","family":"De Stefani","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit ASST Bergamo Ovest  Treviglio Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Nardone","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit ASST Bergamo Ovest  Treviglio Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Abramo","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Portogruaro Hospital  Portogruaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinidh","family":"Paleri","sequence":"additional","affiliation":[{"name":"International Centre for Recurrent Head and Neck Cancer The Royal Marsden Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9639-4486","authenticated-orcid":false,"given":"Fausto","family":"Petrelli","sequence":"additional","affiliation":[{"name":"Oncology Unit ASST Bergamo Ovest  Treviglio 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