{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:54:44Z","timestamp":1791618884835,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective(s)<\/jats:title>\n                    <jats:p>GLP\u20101 receptor agonists (GLP\u20101s) are widely prescribed for type 2 diabetes (T2DM) and obesity, but associated hair loss outcomes remain poorly characterized. We evaluated whether GLP\u20101s were associated with different subtypes of hair loss in adults with T2DM or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective TriNetX cohort study included adults with established care from 2018 to 2025. GLP\u20101 users were grouped by indication and propensity score matched to nonusers by demographics, comorbidities, and hair loss\u2010associated medications. Outcomes were new diagnoses of nonscarring alopecia, telogen effluvium, and alopecia areata as a negative control. Hair loss outcomes were assessed at 1, 3, and 5\u2009years after semaglutide initiation and 1, 1.5, and 2\u2009years after tirzepatide initiation. Secondary analyses compared semaglutide and tirzepatide with other GLP\u20101s and evaluated differences in follow\u2010up BMI between patients with and without hair loss outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Semaglutide and tirzepatide were associated with higher odds of other nonscarring alopecia across T2DM and BMI cohorts. Telogen effluvium odds were elevated with semaglutide use at 3 and 5\u2009years and with tirzepatide at all follow\u2010up periods. Compared with other GLP\u20101s, both medications showed higher odds of other nonscarring alopecia; tirzepatide also showed higher odds of telogen effluvium. Follow\u2010up BMI was lower in GLP\u20101 users with hair loss than without hair loss. Alopecia areata was not associated with GLP\u20101 use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Semaglutide and tirzepatide were associated with higher odds of nonscarring hair loss, particularly telogen effluvium. This association and follow\u2010up BMI findings suggest that weight loss\u2010associated physiologic stress may contribute to hair loss during GLP\u20101 therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70810","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:07:17Z","timestamp":1787760437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nonscarring Alopecia in Adults Treated With\n                    <scp>GLP<\/scp>\n                    \u20101s: A Propensity Score Matched\n                    <scp>TriNetX<\/scp>\n                    Cohort Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-5429","authenticated-orcid":false,"given":"Rishi","family":"Katragadda","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0415-8046","authenticated-orcid":false,"given":"Jamil","family":"Hayden","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-4311","authenticated-orcid":false,"given":"Abdul K.","family":"Saltagi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-3995","authenticated-orcid":false,"given":"Alexandra F.","family":"Welschmeyer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-4774","authenticated-orcid":false,"given":"Humzah A.","family":"Quereshy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1763-5067","authenticated-orcid":false,"given":"Daniel","family":"Karasik","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-7512","authenticated-orcid":false,"given":"Cyrus C.","family":"Rabbani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikrishna C.","family":"Gourishetti","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-7432","authenticated-orcid":false,"given":"Amanda M.","family":"Goslawski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102782"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.18219"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68390"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdrv.2025.04.009"},{"key":"e_1_2_9_6_1","volume-title":"Victoza (Liraglutide) Injection: Approval Letter","author":"Food and Drug Administration","year":"2010"},{"key":"e_1_2_9_7_1","volume-title":"Trulicity (dulaglutide): Approval Letter","author":"Food and Drug Administration","year":"2014"},{"key":"e_1_2_9_8_1","volume-title":"Ozempic (Semaglutide): Approval Letter","author":"Food and Drug Administration","year":"2017"},{"key":"e_1_2_9_9_1","volume-title":"Saxenda (Liraglutide) Injection: Approval Letter for Chronic Weight Management","author":"Food and Drug Administration","year":"2014"},{"key":"e_1_2_9_10_1","volume-title":"Wegovy (Semaglutide): Approval Letter for Chronic Weight Management","author":"Food and Drug Administration","year":"2021"},{"key":"e_1_2_9_11_1","volume-title":"Approval Letter for NDA 215866: Mounjaro (Tirzepatide) Injection","author":"U.S. Food and Drug Administration","year":"2022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010025\u201001859\u20106"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000544023"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13050127"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.92454"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20197"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557\u2010024\u201007613\u2010w"}],"container-title":["The 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