{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:14:39Z","timestamp":1788488079444,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate a two\u2010stage tracheal reconstruction strategy for repairing extensive tracheal defects in well\u2010differentiated thyroid carcinoma (WDTC) with tracheal invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010four patients underwent tumor resection and tracheal excision, followed by staged reconstruction using a free posterior tibial flap (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928), pedicled thoracoacromial flap (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936), or pedicled supraclavicular flap (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910). Functional recovery, decannulation, complications, and survival were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Demographic characteristics were comparable across groups. Tracheal defects were significantly larger in the free posterior tibial artery perforator flap group (9.14\u2009\u00b1\u20091.57 rings) versus the pedicled thoracoacromial (5.89\u2009\u00b1\u20092.59 rings) and supraclavicular (6.30\u2009\u00b1\u20091.49 rings) flap groups. The overall endotracheal tube removal rate was 95.9%, with no intergroup differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.533). Functional recovery (swallowing, speech, and respiration) was comparable among groups. The 3\u2010year survival rate was 78.4%, with no significant differences across groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.633).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two\u2010stage tracheal reconstruction is a safe and effective approach for long\u2010segment tracheal defects in WDTC patients, offering satisfactory functional recovery. Further studies with larger cohorts and longer follow\u2010up are warranted to confirm long\u2010term efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70875","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:06:08Z","timestamp":1788487568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two\u2010Stage Tracheal Repair for Well\u2010Differentiated Thyroid Carcinoma With Tracheal Invasion"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4731-6520","authenticated-orcid":false,"given":"Leyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1774-4025","authenticated-orcid":false,"given":"Xiaoran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5861-0348","authenticated-orcid":false,"given":"Pengwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-4512","authenticated-orcid":false,"given":"Zheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Qilu Hospital of Shandong University  Jinan China"},{"name":"NHC Key Laboratory of Otorhinolaryngology Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2152-368X","authenticated-orcid":false,"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Head and Neck Surgical Center West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Head and Neck Surgical Center West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1530\/EC-13-0056","article-title":"The Age Factor in Survival of a Population Cohort of Well\u2010Differentiated Thyroid Cancer","volume":"2","author":"Mazurat A.","year":"2013","journal-title":"Endocrine Connections"},{"issue":"4","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3390\/cancers13040797","article-title":"Surgical Management of Tracheal Invasion by Well\u2010Differentiated Thyroid Cancer","volume":"13","author":"Matsumoto F.","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"4","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/lary.20800","article-title":"The Management of Thyroid 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J.","year":"2014","journal-title":"Proceeds of an International Society of Cell Therapy Pulmonary Cellular Therapy Signature Series Workshop, Paris, France, April 22, 2014. Cytotherapy"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s42234-019-0031-1","article-title":"3D\u2010Bioprinted Tracheal Reconstruction: An Overview","volume":"5","author":"Frejo L.","year":"2019","journal-title":"Bioelectronic Medicine"},{"issue":"6","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.anl.2022.04.004","article-title":"Analysis of Various Defects and Reconstructive Methods After Invasive Thyroid Carcinoma Resection","volume":"49","author":"Hamahata A.","year":"2022","journal-title":"Auris Nasus Larynx"},{"issue":"9","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1002\/hed.25850","article-title":"Simultaneous Tracheal and Esophageal Reconstruction for Thyroid Cancer Involving Trachea and Esophagus Using a Free Bipaddled Posterior Tibial Artery Perforator Flap","volume":"41","author":"Liu J.","year":"2019","journal-title":"Head & Neck"},{"key":"e_1_2_12_10_1","first-page":"e7","article-title":"Versatility of the Supraclavicular Flap in Head and Neck Reconstruction","volume":"20","author":"Carvalho F. 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C.","year":"2025","journal-title":"Archives of Craniofacial Surgery"},{"issue":"1","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen B. R.","year":"2016","journal-title":"Thyroid"},{"issue":"10","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/hed.23619","article-title":"Management of Invasive Well\u2010Differentiated Thyroid Cancer: An American Head and Neck Society Consensus Statement. AHNS Consensus Statement","volume":"36","author":"Shindo M. 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