{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:08:19Z","timestamp":1788772099248,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Nasal septal perforation (NSP) disrupts normal nasal physiology and may lead to significant functional symptoms. This study aimed to prospectively evaluate changes in olfactory function, nasal mucociliary clearance (MCC), and quality of life (QOL) following septal perforation repair using a fascia lata\u2013costal cartilage sandwich graft (FLCCSG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty patients undergoing septal perforation repair via an open rhinoplasty approach with interposition of a FLCCSG were included. Olfactory function was assessed using the Sniffin\u2019 Sticks test, MCC using the Andersen saccharin test and QOL using the SNOT\u201022 questionnaire preoperatively and at 1, 3, and 6\u2009months postoperatively. Functional outcomes were analyzed longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the end of the 6\u2010month follow\u2010up, complete closure of the septal perforation was achieved in all patients. A\u00a0statistically significant improvement in total olfactory scores (TOS) and MCC times was observed at the postoperative 3rd\u00a0and\u00a06th\u00a0months compared to the preoperative period (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). SNOT\u201022 scores showed significant improvement at the\u00a0postoperative 1st, 3rd, and 6th months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean increase in TOS was 7.33 (95% CI: 4.84\u20139.82), while MCC time decreased by 312.7\u2009s (95% CI: \u2212480.43 to \u2212144.96) and SNOT\u201022 scores decreased by 18.8 points (95% CI: \u221224.32 to \u221213.27). No correlation was found between perforation size and functional outcomes. Smoking was associated with less improvement in olfactory function, while patients with perforations secondary to septal surgery exhibited greater functional recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Septal perforation repair using a FLCCSG results in significant and progressive improvements in olfactory function, MCC, and QOL beyond anatomical closure alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>4<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.70892","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:15:12Z","timestamp":1788768912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Septal Perforation Repair Improves Olfaction and Mucociliary Clearance: A Prospective Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-9136","authenticated-orcid":false,"given":"Rag\u0131p \u00c7a\u011flar","family":"\u00c7elik","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Sultanbeyli State Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-5059","authenticated-orcid":false,"given":"Deniz","family":"Hanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Health Sciences, Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-4208","authenticated-orcid":false,"given":"Yavuz","family":"Uyar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Health Sciences, Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-023X","authenticated-orcid":false,"given":"G\u00fclpembe","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Health Sciences, Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11882-018-0754-1","article-title":"Nasoseptal Perforation: From Etiology to Treatment","volume":"18","author":"Pereira C.","year":"2018","journal-title":"Current Allergy and Asthma Reports"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.clinimag.2017.02.002","article-title":"Imaging Prevalence of Nasal Septal Perforation in an Urban Population","volume":"43","author":"Gold M.","year":"2017","journal-title":"Clinical Imaging"},{"issue":"6","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.clindermatol.2014.02.022","article-title":"Nasal Septal Ulceration","volume":"32","author":"Sardana K.","year":"2014","journal-title":"Clinics in Dermatology"},{"issue":"2","key":"e_1_2_11_5_1","first-page":"72","article-title":"Prevalence of Nasal Septal Perforation: The Sk\u00f6vde Population\u2010Based Study","volume":"41","author":"Oberg D.","year":"2003","journal-title":"Rhinology"},{"issue":"5","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S002221510700566X","article-title":"Different Surgical Treatments for Nasal Septal Perforation and Their Outcomes","volume":"121","author":"Goh A. 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Our Experience","volume":"26","author":"Re M.","year":"2006","journal-title":"Acta Otorhinolaryngologica Italica"},{"issue":"5","key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.amjoto.2019.07.008","article-title":"Olfaction and Quality of Life in Patients With Nasal Septal Deviation Treated With Septoplasty","volume":"40","author":"Valsamidis K.","year":"2019","journal-title":"American Journal of Otolaryngology"},{"issue":"1","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/coa.12463","article-title":"The Outcome of Septorhinoplasty Surgery on Olfactory Function","volume":"41","author":"Randhawa P. 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